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Chi-Hsien Liu


Chi-Hsien Liu, Professor 

Education: PhD. of Chemical Engineering; National Tsing

Hua   University,Taiwan

Interests:  Stem cell technology, Nanotechnology,

Drug delivery, Biochemical engineering

Telephone: 886-3-2118800 Ext: 3146

E-mail: chl@mail.cgu.edu.tw   

Laboratory: Cell Engineering Lab



09/1998-06/2001      Ph.D. in Chemical Engineering; National Tsing Hua University, Taiwan

09/1990-06/1992      M.S. in Chemical Engineering; Tatung University , Taiwan

09/1986-06/1990       B.S. in Bio Engineering; Tatung University , Taiwan



08/2018-present  Professor, Department Chemical and Materials Engineering ; Chang Gung University, Taiwan

08/2013-07/2018  Professor, Institute of Biochemical and Biomedical Engineering; Chang Gung University, Taiwan

08/2007-07/2013   Associate Professor, Institute of Biochemical and Biomedical  Engineering; Chang Gung University, Taiwan

08/2003-07/2007   Assistant Professor, Institute of Biochemical and Biomedical Engineering; Chang Gung University, Taiwan

08/2002-07/2003   Scientist Fellow, Food Industry Research Development Institute (FIRDI)

10/2001-07/2002   R&D manager, Widex Biotech. Co.

04/2001-09/2001   Project manager, Analytica Biotech. Co.

08/1992-08/1998  Associate Scientist Fellow, FIRDI



Drug delivery

Stem cell technology

Biochemical engineering




Member, Biochemical Engineering Society of Taiwan (BEST)

Member, Biomedical Engineering Society of ROC

Overseas Member, Society for Biotechnology, Japan



Journal Reviewer, Biochemical Engineering Journal

Journal Reviewer, Process Biochemistry

Journal Reviewer, Cytotherapy

Journal Reviewer, International Journal of Pharmaceutics

Journal Reviewer, Journal of the Chinese Institute of Chemical Engineers

Conference Reviewer, Annual Symposium of the Biochemical Engineering Society of Taiwan



Special contribution Award for FIRDI; (1998)

Program Execution Award from Ministry of Economic Affairs (1998)



  1. Liu, C. H.*, Liu, Y. X., Wu, W. C. Facile development of medium optimization for antibody production: Implementation in spinner flask and hollow fiber reactor, Cytotechnology, 2018, 70, 1631-1642 Biotechnology & Applied Microbiology, 119/160 (74 %) (Available online 04 November 2018), IF 1.461,
  2. Kumari, M., Liu, C. H.*, Wu, W. C. Protein moiety in oligochitosan modified vector regulates internalization mechanism and gene delivery: Polyplex characterization, intracellular trafficking and transfection. Carbohydrate Polymers, 2018, 202, 143-156 Chemistry, Applied, 2/71 (3 %) (Available online 31 August 2018), IF 5.158,
  3. Rout, B., Liu, C. H.*, Wu, W. C. Increased anti-biofilm efficacy of toluidine blue on Staphylococcus species after nano-encapsulation. Photodiagnosis and Photodynamic Therapy, 2018, 21(3) 190–200, IF 2.895, Oncology 127/222 (Available online 13 December 2017)
  4. Kumari, M., Liu, C. H.*, Wu, W. C. Efficient gene delivery by oligochitosan conjugated serum albumin: Facile synthesis, polyplex stability, and transfection, Carbohydrate Polymers, 2018, 183(3) 37-49, Chemistry, Applied, 2/71 (3%) (Available online 04 November 2017), IF 5.158,
  5. Rout, B., Liu, C. H.*, Wu, W. C. Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function, Scientific Reports, 2017, 7, Article number: 7892, doi:10.1038/s41598-017-07444-w, Published online: 11 August 2017, IF 4.259, Multidisciplinary Sciences 10/64 (16%)
  6. Sahoo, S. L, Liu, C. H.*, Wu, W.C., 2017, Lymphoma cell isolation using multifunctional magnetic nanoparticles: antibody conjugation and characterization. RCS Advances, 7, 22468–22478.online 13 Apr 2017 IF 3.108, Chemistry, Multidisciplinary 59/166 (36%)
  7. Liu, C. H.*, Lai, H.Y., Wu, W.C., 2017, Facile Synthesis of magnetic iron oxide nanoparticles for nattokinase isolation, Food and Bioproducts Processing, 102,260-267, IF 1.97, Food Science & Technology, 45/128 (35%),  Engineering, Chemical 56/135 (41%) online 1 March 2017
  8. Liu, C. H.*, Tsao, M.H., Sahoo, S. L, Wu, W. C. 2017, Magnetic nanoparticles with fluorescence and affinity for DNA sensing and nucleus staining, RSC Advances, 7, 5937-5947 (published online 17 Jan 2017) IF 3.108, Chemistry, Multidisciplinary 59/166 (36%)
  9. Hwang Y. S., Liu, C. H, Huang Y. C., Chen C. S., Chen T. L., Wang N. K., Chen Y. P., Chen K. J., Lai C. C., Wu W. C., 2017, Systemic effects after intravitreal injection of bevacizumab in new born rabbit eyes. Cutaneous and Ocular Toxicology, IF1.213, Ophthalmology 47/59 (80%)
  10. Liu, C. H.*, Lee, W.S., Wu, W. C. 2016, Photodynamic inactivation against Pseudomonas aeruginosa by curcumin microemulsions, RSC Advances, 6, 63013-63022, IF 3.108, Chemistry, Multidisciplinary 59/165 (33%) First published online 01 Jul 2016  IF =3.289
  11. Rout, B., Liu, C. H.*, Wu, W. C. 2016, Enhancement of photodynamic inactivation against Pseudomonas aeruginosa by a nano-carrier approach. Colloids and Surfaces B: Biointerfaces, 140:472-480. IF 3.902, Chemistry, Physical 39/144 (27%) online 2016 Jan 6. IF=3.902
  12. Liu, C. H.*, Huang, Y. C., Jhang, J. W., Liu, Y. H., Wu, W. C., 2015 Quercetin delivery to porcine cornea and sclera by solid lipid nanoparticles and nanoemulsion, IF 3.289, RSC Advances, 5, 100923 – 100933, IF 3.289Chemistry, Multidisciplinary 49/163(33%) online 24 Nov 2015
  13. Sahoo, S. L, Liu, C. H.*, 2015, Adsorption behaviors of DNA by modified magnetic nanoparticles: Effect of spacer and salt, Colloids and Surfaces A: Physicochem. Eng. Aspects, 482, 184–194, IF 2.76, Chemistry, Physical 56/144 (39%) online 21 May 2015
  14. Liu, C. H.*, Lai, K.Y., Wu, W.C., Chen,Y.J., Lee, W.S., Hsu, C.Y., 2015, In vitro scleral lutein distribution by cyclodextrin containing nanoemulsions, Chemical Pharmaceutical Bulletin, 63(2), 59-67, IF 1.375, Chemistry, Multidisciplinary 76/148 (51%)
  15. Liu, C. H.*, Chiu, H.C., Wu, W.C., Sahoo, S.L., Hsu, C.Y., 2014, Novel lutein loaded lipid nanoparticles on porcine corneal distribution, Journal of Ophthalmology, Volume 2014, Article ID 304694. IF 1.463   Ophthalmology 34/56 (60%)
  16. Wu, W C, Liu, C. H, Wang, N.K., Chen, K.J., Chen T.L., Hwang, Y.S., Liao, P.J., Li, L.M., Lai, C.C., 2014, Lens subluxation after plasmin and SF6 injections in rabbit eyes, Plos One,9 (11) e1129573. (IF: 3.057) Multidisciplinary Sciences 11/66 (16%)
  17. Liu, C. H.*, Sahoo, S.L. Tsao, M.H., 2014, Acridine orange coated magnetic nanoparticles for nucleus labeling and DNA adsorption, Colloids and Surfaces B: Biointerfaces, 115, 150-156 (IF: 4.152)


Liu, C. H., Hwang, S. M., Serum-free cell culture system, In: First Mr. Hsieh Memorial Award  Proceeding. p201-228, 2004


1. Optimizing culture medium for CD34+ hematopoietic cell expansion. 2014, USP 8,762,074 B2

2. Purification methods of blood plasminogen, 2014, ROC Patent I460188

3. Microorganisms and process for fermented black tea beverage, 2000, Japan Patent 3084348 ; ROC Patent 385335