Jyh-Ping Chen

Professor
Bioengineering Laboratory
Tel.: (03) 2118800 Ext 5298
Fax: (03) 2118668
E-mail: jpchen@mail.cgu.edu.tw
Address: 259 Wen-Hwa First Road, Kwei-Shan, Taoyuan 33302, Taiwan
Experience |
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Department of Chemical and Materials Engineering, Chang Gung University, ROC |
Professor |
1997/08~ |
Department of Chemical and Materials Engineering, Chang Gung University, ROC |
Professor and Head |
2006/08~2014/01 |
Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, ROC |
Professor and Director |
2002/08~2006/07 |
Institute of Basic Medical Sciences, University of Tsukuba, Japan |
Visiting Foreign Researcher |
2000/07~2000/09 |
Department of Chemical Engineering and Materials Science, University of Minnesota, MN, USA |
Visiting Professor |
1998/07~1998/09 |
Department of Chemical Engineering and Materials Engineering, Chang Gung University, ROC |
Associate Professor |
1994/08~1997/07 |
Department of Chemical Engineering, National Cheng Kung University, ROC |
Associate Professor |
1991/08~1994/08 |
Center for Dairy Research, University of Wisconsin-Madison, WI, USA |
Assistant Scientist |
1988/09~1991/08 |
Molecular Biology Division, United Biomedical Inc., USA |
Research Associate |
1988/01~1988/08 |
Education |
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Pennsylvania State University, USA |
PhD in Chemical Engineering |
1988 |
Pennsylvania State University, USA |
MS in Chemical Engineering |
1985 |
National Taiwan University, ROC |
BS in Chemical Engineering |
1981 |
Research Fields and Expertise |
1. Biomaterials 2. Tissue Engineering 3. Nanomedicine 4. Drug and Gene Delivery 5. Biomedical Nanotechnology 6. Biochemical Engineering |
Recent Publications |
Full list of publications at here 1. G. Jose, Y.J. Lu, J.T. Hung, A.L. Yu, J.P. Chen.* 2020. Co-delivery of CPT-11 and panobinostat with anti-GD2 antibody conjugated immunoliposomes for targeted combination chemotherapy. Cancers, 12:3211. 2. H.T. Liao, Y.T. Lai, C.Y. Kuo, J.P. Chen.* 2020. A bioactive multi-functional heparin-grafted aligned poly(lactide-co-glycolide)/curcumin nanofiber membrane to accelerate diabetic wound healing, Materials Science and Engineering: C, 119:111689. 3. V. Sokolova, K. Kostka, K.T. Shalumon, O. Prymak, J.P. Chen,* M. Epple.* 2020. Synthesis and characterization of PLGA/HAP scaffolds with DNA-functionalised calcium phosphate nanoparticles for bone tissue engineering, Journal of Materials Science: Materials in Medicine, 31:102. 4. Y.J. Lu, Y.H. Lan, C.C. Chuang, W.T. Lu, L.Y. Chan, P.W. Hsu, J.P. Chen.* 2020. Injectable thermo-sensitive chitosan hydrogel containing CPT-11-loaded EGFR-targeted graphene oxide and SLP2 shRNA for localized drug/gene delivery in glioblastoma therapy. International Journal of Molecular Sciences, 21:7111. 5. M.Y. Lan, Y.B. Hsu, M.C. Lan, J.P. Chen,* Y.J. Lu.* 2020. Polyethylene glycol-coated graphene oxide loaded with erlotinib as an effective therapeutic agent for treating nasopharyngeal cancer cells. Internatinal Journal of Nanomedicine, 15, 7569-7582. 6. Z.H. Liu, Y.C. Huang, C.Y. Kuo, C.Y. Kuo, C.Y. Chin, P.K. Yip, J.P. Chen.* 2020. Docosahexaenoic acid-loaded polylactic acid core-shell nanofiber membranes for regenerative medicine after spinal cord injury: in vitro and in vivo study. International Journal of Molecular Sciences, 21:7031. 7. Y.J. Lu, Y.H. Wang, R.S. Sahu, J.P. Chen, B.S. Dash, P.J. Chung, H.W. Yang, E.Y. Chuang, T.L. Hwang. 2020. Mechanism of nanoformulated graphene oxide-mediated human neutrophil activation. ACS Applied Materials & Interfaces 12, 40141-40152. 8. Anilkumar T. S., Y.J. Lu, J.P. Chen.* 2020. Optimization of the preparation of magnetic liposomes for the combined use of magnetic hyperthermia and photothermia in dual magneto-photothermal cancer therapy. International Journal of Molecular Sciences 21:5187. 9. H.A. Chen, Y.H. Ma, T.Y. Hsu, J.P. Chen.* 2020. Preparation of peptide and recombinant tissue plasminogen activator conjugated poly(lactic-co-glycolic acid) (PLGA) magnetic nanoparticles for dual targeted thrombolytic therapy. International Journal of Molecular Sciences, 21:2690. 10. G. Jose, K.T. Shalumon, H.T. Liao, C.Y. Kuo, J.P. Chen.* 2020. Preparation and characterization of surface heat sintered nanohydroxyapatite and nanowhitlockite embedded poly (lactic-co-glycolic acid) microsphere bone graft scaffolds: in vitro and in vivo studies. International Journal of Molecular Sciences, 21:528. 11. G. Jose, K.T. Shalumon,* J.P. Chen.* 2020. Natural polymers based hydrogels for cell culture applications. Current Medicinal Chemistry, 27, 2734-2776. 12. F.C.S. Chang, C.G. Wallace, Y.C. Hsiao, J.J. Huang, C.S.W. Liu, Z.C. Chen, P.K.T. Chen, J.P. Chen, Y.R. Chen. 2020. Long-term comparison study of philtral ridge morphology with two different techniques of philtral reconstruction. International Journal of Oral and Maxillofacial Surgery, ,49, 1254-1259. 13. C.S. Liu, Y.C. Hsiao, J.J. Huang, J.P. Chen, D. Pascasio, C.S. Chang, L.J. Lo, P.K. Chen, Y.R. Chen, P.K. Ku. 2020. Secondary unilateral cleft rhinoplasty utilizing natural curvature of rib cartilage as alar rim graft: a 3 dimensional evaluation of long term results. Plastic and Reconstructive Surgery, 145, 775-779. 14. C.T. Chen, C.H. Chen, C. Sheu, J.P. Chen.* 2019. Ibuprofen-loaded hyaluronic acid nanofibrous membranes for prevention of postoperative tendon adhesion through reduction of inflammation. International Journal of Molecular Sciences, 20:5038. 15. H.H. Kao, C.Y. Kuo, K.S. Chen, J.P. Chen.* 2019. Preparation of gelatin and gelatin/hyaluronic acid cryogel scaffolds for the 3D culture of mesothelial cells and mesothelium tissue regeneration. International Journal of Molecular Sciences, 20:4527. 16. Y. H Ma, C. H. Liu, Y. Liang, J. P. Chen, T. Wu. 2019. Targeted delivery of plasminogen activators for thrombolytic therapy: an integrative evaluation. Molecules, 24:3407. 17. C.H. Liu,# H.L. Hsu,#J.P. Chen,#T. Wu, Y.H. Ma. 2019. Thrombolysis induced by intravenous administration of plasminogen activator in magnetoliposomes: dual targeting by magnetic and thermal manipulation, Nanomedicine: Nanotechnology, Biology, and Medicine, 20, 101992. 18. K.T. Shalumon, H.-T. Liao, C.-Y. Kuo, C.-B. Wong, C.-J. Li, Mini P.A., J.P. Chen.* 2019. Rational design of gelatin/nanohydroxyapatite cryogel scaffolds for bone regeneration by introducing chemical and physical cues to enhance osteogenesis of bone marrow mesenchymal stem cells. Materials Science & Engineering C, 104:109855. 19. Anilkumar T.S., K.T. Shalumon, J.P. Chen.* 2019. Applications of magnetic liposomes in cancer therapies. Current Pharmaceutical Design, 25:1490-1504. 20. Y.J. Lu, E.Y. Chuang, Y.H. Cheng, H.A Chen, J.P. Chen.* 2019. Thermosensitive magnetic liposomes for alternating magnetic field-inducible drug delivery in dual targeted brain tumor chemotherapy. Chemical Engineering Journal, 373:720-733. 21. A. Jayasree, K.T. Shalumon, R. Ramachandran, M.N. Sundaram, C.H. Chen, U. Mony, J.P. Chen,* R. Jayakumar.* 2019. Bioengineered braided micro−nano (multiscale) fibrous scaffolds for tendon reconstruction. ACS Biomaterials Science and Engineering, 5, 1476-1486. 22. C.S. Chang, S. Lin, C.G. Wallace, Y.C. Hsiao, C.M. Lin, G.C.W. Kang, Z.C. Chen, P.K.T. Chen, L.J. Lo, Y.R. Chen, J.P. Chen.* 2019. Masseter muscle volume changes evaluated by 3-dimensional computed tomography after repeated botulinum toxin a injections in patients with square facial morphology. Annals of Plastic Surgery, 82, S29-S32. 23. G. Jose, Y.J. Lu, H.A. Chen, H.L. Hsu, J.T. Hung, Anilkumar T.S., J.P. Chen.* 2019. Hyaluronic acid modified bubble-generating magnetic liposomes for targeted delivery of doxorubicin. Journal of Magnetism and Magnetic Materials, 474, 355-364. 24. M.N. Sundaram, S.D., U. Mony, K.T. Shalumon, J.P. Chen, R. Jayakumar. 2019. Chitosan hydrogel scaffold reinforced with twisted poly(l-lactic acid) aligned microfibrous bundle to mimic tendon extracellular matrix. International Journal of Biological Macromolecules, 122, 37-44. 25. Anilkumar T.S., Y.J. Lu, H.A. Chen, H.L. Hsu, G. Jose, J.P. Chen.* 2019. Dual targeted magnetic photosensitive liposomes for photothermal/photodynamic tumor therapy. Journal of Magnetism and Magnetic Materials, 473, 241-252. 26. G.C. Kang, Y.C. Hsiao, J.J. Huang, J.P. Chen, P.K. Chen, Y.R. Chen, C.S. Chang. 2019. Aesthetic durable forehead contouring in asians with fat grafting and botulinum toxin. Annals of Plastic Surgery, 82, S59-S65. 27. H.T. Liao, M.J. Tsai, M. Brahmayya, J.P. Chen.* 2018. Bone regeneration using adipose-derived stem cells in injectable thermo-gelling hydrogel scaffold containing platelet-rich plasma and biphasic calcium phosphate. International Journal of Molecular Sciences, 19:2537. 28. K.T. Shalumon, C.Y. Kuo, C.B. Wong, Y.M. Chien, H.A. Chen, J.P. Chen.* 2018. Gelatin/nanohyroxyapatite cryogel embedded poly(lactic-co-glycolic acid)/ nanohydroxyapatite microsphere hybrid scaffolds for simultaneous bone regeneration and load-bearing. Polymers, 10:620. 29. C.H. Chen, C.Y. Kuo, S.H. Chen, S.H. Mao, C.Y. Chang, K.T. Shalumon, J.P. Chen.* 2018. Thermosensitive injectable hydrogel for simultaneous intraperitoneal delivery of doxorubicin and prevention of peritoneal adhesion. International Journal of Molecular Sciences, 19:1373. 30. C.S. Chang, CG. Wallace, Y.C. Hsiao, J.J. Huang, Z.C. Chen, C.J. Chang, L.J. Lo, P.K.T. Chen, J.P. Chen, Y.R. Chen. 2018. Clinical evaluation of silicone gel in the treatment of cleft lip scars. Scientific Reports, 8:7422. 31. K.T. Shalumon, C. Sheu, C.H. Chen, S.H. Chen, G. Jose, C.Y. Kuo, J.P. Chen.* 2018. Multi-functional electrospun antibacterial core-shell nanofibrous membranes for prolonged prevention of post-surgical tendon adhesion and inflammation. Acta Biomaterialia, 72, 121-136. 32. Y.J. Lu, P.Y. Lin, P.H. Huang, C.Y. Kuo, K.T. Shalumon, M.Y. Chen, J.P. Chen.* 2018. Magnetic graphene oxide for dual targeted delivery of doxorubicin and photothermal therapy. Nanomaterials, 8:193. 33. K.T. Shalumon, J. Anjana, U. Mony, R. Jayakumar, J.P. Chen.* 2018. Process study, development and degradation behavior of different size scale electrospun poly(caprolactone) and poly(lactic acid) fibers. Journal of Polymer Research, 25:82. 34. C.H. Chen, C.Y. Kuo, J.P. Chen.* 2018. Effect of cyclic dynamic compressive loading on chondrocytes and adipose-derived stem cells co-cultured in highly elastic cryogel scaffolds. Internartional Journal of Molecular Scieinces, 19:370 35. C.S. Chang, C.G. Wallace, Y.C. Hsiao, T.C. Lu, S.H. Chen, F.C. Chan, P. K.T. Chen, J.P. Chen, C.J. Chang and M. S. Noordhoff. 2017. Patient and parent reported outcome measures in cleft lip and palate patients before and after secondary alveolar bone grafting. Medicine, 96:52 36. T.E. Lin, Y.J. Lu, C.L. Sun, H. Pick, J.P. Chen, A. Lesch, H.H. Girault. 2017. From tissues to organs: soft electrochemical probes for mapping the distribution of biomarkers and injected nanomaterials in animal and human tissues. Angewandte Chemie International Edition, 56, 16498-16502. 37. Y.T. Fong, C.H. Chen, J.P. Chen.* 2017. Intratumoral delivery of doxorubicin on folate-conjugated graphene oxide by in-situ forming thermo-sensitive hydrogel for breast cancer therapy. Nanomaterials, 7:388. 38. P.Y. Chou, S.H. Chen, C.H. Chen, S.H. Chen, Y.T Fong, J.P. Chen.* 2017. Thermo-responsive in-situ forming hydrogels as barriers to prevent post-operative peritendinous adhesion. Acta Biomaterialia, 63, 85-95. 39. C.S. Chang,, C.G. Wallace, Y.C. Hsiao, Y.J. Hsieh, Y.C. Wang, N.H. Chen, Y.F. Liao, E.J.W. Liou, P.K.T. Chen, J.P. Chen, Y.R. Chen. 2017. Airway changes after cleft orthognathic surgery evaluated by three-dimensional computed tomography and overnight polysomnographic study. Scientific Reports, 7:12260. 40. C.H Chen, S.H. Chen, C.Y. Kuo, M.L. Li, J.P. Chen.* 2017. Response of dermal fibroblasts to biochemical and physical cues in aligned polycaprolactone/silk fibroin nanofiber scaffolds for application in tendon tissue engineering. Nanomaterials, 7:219. 41. C.H. Chen, S.H. Chen, S.H. Mao, M.J. Tsai, P.Y. Chou, C.H. Liao, J.P. Chen.* 2017. Injectable thermosensitive hydrogel containing hyaluronic acid and chitosan as a barrier for prevention of postoperative peritoneal adhesion. Carbohydrate Polymers, 173, 721-731. 42. C.L. Yang,#J.P. Chen,# K.C. Wei, J.Y. Chen, C.W. Huang, Z.X. Liao. 2017. Release of doxorubicin by a folate-grafted, chitosan-coated magnetic nanoparticle. Nanomaterials, 7:85. 43. S. Lin, Y.C. Hsiao, Y. C., J.J. Huang, C.S. Chang, P.K. Chen, J.P. Chen, L.J. Lo, Y.R. Chen. 2017. Minimal invasive rhinoplasty: fat injection for nasal dorsum contouring. Annals of Plastic Surgery, 78, S117-S123. 44. H.L. Hsu, J.P. Chen.* 2017. Preparation of thermosensitive magnetic liposome encapsulated recombinant tissue plasminogen activator for targeted thrombolysis. Journal of Magnetism and Magnetic Materials, 427, 188-194. 45. Y.C. Lu, F.Y. Chang, S.J. Tu, J.P. Chen, Y.H. Ma. 2017. Cellular uptake of magnetite nanoparticles enhanced by NdFeB magnets in staggered arrangement. Journal of Magnetism and Magnetic Materials, 427, 71-80. 46. Y.S. Huang, Y.J. Lu, J.P. Chen.* 2017. Magnetic graphene oxide as a carrier for targeted delivery of chemotherapy drugs in cancer therapy. Journal of Magnetism and Magnetic Materials, 427, 34-40. 47. K.T. Shalumon, C. Sheu, Y.T. Fong, H.T. Liao, J.P. Chen.* 2016. Microsphere-based hierarchically juxtapositioned biphasic scaffolds prepared from poly(lactic-co-glycolic acid) and nanohydroxyapatite for osteochondral tissue engineering. Polymers, 8:429. 48. C.H. Chen, C.Y. Kuo, Y.J. Wang, J.P. Chen.* 2016. Dual function of glucosamine in gelatin/hyaluronic acid cryogel to modulate scaffold mechanical properties and to maintain chondrogenic phenotype for cartilage tissue engineering. International Journal of Molecular Sciences, 17:1957. 49. C. Sheu, K.T. Shalumon, C.H. Chen, C.Y. Kuo, Y.T. Fong, J.P. Chen.* 2016. Dual crosslinked hyaluronic acid nanofibrous membranes for prolonged prevention of post-surgical peritoneal adhesion. Journal of Materials Chemistry B, 4, 6680-6693. 50. C.S. Chang, C.G. Wallace, Y.C. Hsiao, Y.T. Chiu, B.C.J. Pai, I.J. Chen, Y.F. Liao, E.J.W. Liou, P.K.T. Chen, J.P. Chen, M.S. Noordhoff. 2016. Difference in the surgical outcome of unilateral cleft lip and palate patients with and without pre-alveolar bone graft orthodontic treatment. Scientific Reports, 6:23597. 51. C.S. Chang, Y.C. Hsiao, J.J. Huang, J.P. Chen, P.K.T. Chen, G.C.W. Kang. 2016. Aesthetic patient-centric approach to a unilateral zygomaticomaxillary fracture: computer-guided osteotomy of the non-injured side. Aesthetic Surgery Journal, 36(5), NP184-NP186. 52. J.P. Chen,* C.H. Liu, H.L. Hsu, T. Wu, Y.J. Lu, Y.H. Ma. 2016. Magnetically controlled release of recombinant tissue plasminogen activator from chitosan nanocomposites for targeted thrombolysis. Journal of Materials Chemistry B, 4, 25782590. 53. H.T. Liao, K.T. Shalumon, K.H. Chang, C. Sheu, J.P. Chen.* 2016. Investigation of synergistic effects of inductive and conductive factors in gelatin-based cryogels for bone tissue engineering. Journal of Materials Chemistry B, 4, 1827-1841. |