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Jyh-Ping Chen



Bioengineering Laboratory

Tel.: (03) 2118800 Ext 5298

Fax: (03) 2118668

E-mail: jpchen@mail.cgu.edu.tw

Address: 259 Wen-Hwa First Road, Kwei-Shan, Taoyuan 33302, Taiwan



Department of Chemical and Materials Engineering, Chang Gung University, ROC



Department of Chemical and Materials Engineering, Chang Gung University, ROC

Professor and Head


Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, ROC

Professor and Director


Institute of Basic Medical Sciences, University of Tsukuba, Japan

Visiting Foreign Researcher


Department of Chemical Engineering and Materials Science, University of Minnesota, MN, USA

Visiting Professor


Department of Chemical Engineering and Materials Engineering, Chang Gung University, ROC

Associate Professor


Department of Chemical Engineering, National Cheng Kung University, ROC

Associate Professor


Center for Dairy Research, University of Wisconsin-Madison, WI, USA

Assistant Scientist


Molecular Biology Division, United Biomedical Inc., USA

Research Associate




Pennsylvania State University, USA

PhD in Chemical Engineering


Pennsylvania State University, USA

MS in Chemical Engineering


National Taiwan University, ROC

BS in Chemical Engineering



Research Fields and Expertise

1. Biomaterials

2. Tissue Engineering

3. Nanomedicine

4. Drug and Gene Delivery

5. Biomedical Nanotechnology

6. Biochemical Engineering


Recent Publications

Full list of publications at  here

1. G. Jose, Y.J. Lu, J.T. Hung, A.L. Yu, J.P. Chen.* 2020. Co-delivery of CPT-11 and  panobinostat with anti-GD2 antibody conjugated immunoliposomes for targeted  combination chemotherapy. Cancers, 12:3211. 

2. H.T. Liao, Y.T. Lai, C.Y. Kuo, J.P. Chen.* 2020. A bioactive multi-functional  heparin-grafted aligned poly(lactide-co-glycolide)/curcumin nanofiber membrane to  accelerate diabetic wound healing, Materials Science and Engineering: C, 119:111689. 

3. V. Sokolova, K. Kostka, K.T. Shalumon, O. Prymak, J.P. Chen,* M. Epple.* 2020. Synthesis and characterization of PLGA/HAP scaffolds with DNA-functionalised calcium  phosphate nanoparticles for bone tissue engineering, Journal of Materials Science:  Materials in Medicine, 31:102. 

4. Y.J. Lu, Y.H. Lan, C.C. Chuang, W.T. Lu, L.Y. Chan, P.W. Hsu, J.P. Chen.* 2020. Injectable thermo-sensitive chitosan hydrogel containing CPT-11-loaded EGFR-targeted  graphene oxide and SLP2 shRNA for localized drug/gene delivery in glioblastoma therapy.  International Journal of Molecular Sciences, 21:7111. 

5. M.Y. Lan, Y.B. Hsu, M.C. Lan, J.P. Chen,* Y.J. Lu.* 2020. Polyethylene glycol-coated  graphene oxide loaded with erlotinib as an effective therapeutic agent for treating  nasopharyngeal cancer cells. Internatinal Journal of Nanomedicine, 15, 7569-7582. 

6. Z.H. Liu, Y.C. Huang, C.Y. Kuo, C.Y. Kuo, C.Y. Chin, P.K. Yip, J.P. Chen.* 2020. Docosahexaenoic acid-loaded polylactic acid core-shell nanofiber membranes for  regenerative medicine after spinal cord injury: in vitro and in vivo study. International  Journal of Molecular Sciences, 21:7031. 

7. Y.J. Lu, Y.H. Wang, R.S. Sahu, J.P. Chen, B.S. Dash, P.J. Chung, H.W. Yang, E.Y. Chuang,  T.L. Hwang. 2020. Mechanism of nanoformulated graphene oxide-mediated human  neutrophil activation. ACS Applied Materials & Interfaces 12, 40141-40152. 

8. Anilkumar T. S., Y.J. Lu, J.P. Chen.* 2020. Optimization of the preparation of magnetic  liposomes for the combined use of magnetic hyperthermia and photothermia in dual  magneto-photothermal cancer therapy. International Journal of Molecular Sciences  21:5187. 

9. H.A. Chen, Y.H. Ma, T.Y. Hsu, J.P. Chen.* 2020. Preparation of peptide and recombinant  tissue plasminogen activator conjugated poly(lactic-co-glycolic acid) (PLGA) magnetic  nanoparticles for dual targeted thrombolytic therapy. International Journal of Molecular  Sciences, 21:2690. 

10. G. Jose, K.T. Shalumon, H.T. Liao, C.Y. Kuo, J.P. Chen.* 2020. Preparation and  characterization of surface heat sintered nanohydroxyapatite and nanowhitlockite  embedded poly (lactic-co-glycolic acid) microsphere bone graft scaffolds: in vitro and in  vivo studies. International Journal of Molecular Sciences, 21:528. 

11. G. Jose, K.T. Shalumon,* J.P. Chen.* 2020. Natural polymers based hydrogels for cell  culture applications. Current Medicinal Chemistry, 27, 2734-2776. 

12. F.C.S. Chang, C.G. Wallace, Y.C. Hsiao, J.J. Huang, C.S.W. Liu, Z.C. Chen, P.K.T. Chen,  J.P. Chen, Y.R. Chen. 2020. Long-term comparison study of philtral ridge morphology  with two different techniques of philtral reconstruction. International Journal of Oral and  Maxillofacial Surgery, ,49, 1254-1259. 

13. C.S. Liu, Y.C. Hsiao, J.J. Huang, J.P. Chen, D. Pascasio, C.S. Chang, L.J. Lo, P.K. Chen,  Y.R. Chen, P.K. Ku. 2020. Secondary unilateral cleft rhinoplasty utilizing natural  curvature of rib cartilage as alar rim graft: a 3 dimensional evaluation of long term results. Plastic and Reconstructive Surgery, 145, 775-779. 

14. C.T. Chen, C.H. Chen, C. Sheu, J.P. Chen.* 2019. Ibuprofen-loaded hyaluronic acid  nanofibrous membranes for prevention of postoperative tendon adhesion through  reduction of inflammation. International Journal of Molecular Sciences, 20:5038.

15. H.H. Kao, C.Y. Kuo, K.S. Chen, J.P. Chen.* 2019. Preparation of gelatin and  gelatin/hyaluronic acid cryogel scaffolds for the 3D culture of mesothelial cells and  mesothelium tissue regeneration. International Journal of Molecular Sciences, 20:4527. 

16. Y. H Ma, C. H. Liu, Y. Liang, J. P. Chen, T. Wu. 2019. Targeted delivery of plasminogen  activators for thrombolytic therapy: an integrative evaluation. Molecules, 24:3407. 17. C.H. Liu,# H.L. Hsu,#J.P. Chen,#T. Wu, Y.H. Ma. 2019. Thrombolysis induced by  intravenous administration of plasminogen activator in magnetoliposomes: dual targeting  by magnetic and thermal manipulation, Nanomedicine: Nanotechnology, Biology, and  Medicine, 20, 101992. 

18. K.T. Shalumon, H.-T. Liao, C.-Y. Kuo, C.-B. Wong, C.-J. Li, Mini P.A., J.P. Chen.* 2019.  Rational design of gelatin/nanohydroxyapatite cryogel scaffolds for bone regeneration by  introducing chemical and physical cues to enhance osteogenesis of bone marrow  mesenchymal stem cells. Materials Science & Engineering C, 104:109855.  

19. Anilkumar T.S., K.T. Shalumon, J.P. Chen.* 2019. Applications of magnetic liposomes in  cancer therapies. Current Pharmaceutical Design, 25:1490-1504. 

20. Y.J. Lu, E.Y. Chuang, Y.H. Cheng, H.A Chen, J.P. Chen.* 2019. Thermosensitive  magnetic liposomes for alternating magnetic field-inducible drug delivery in dual targeted  brain tumor chemotherapy. Chemical Engineering Journal, 373:720-733. 

21. A. Jayasree, K.T. Shalumon, R. Ramachandran, M.N. Sundaram, C.H. Chen, U. Mony, J.P.  Chen,* R. Jayakumar.* 2019. Bioengineered braided micro−nano (multiscale) fibrous  scaffolds for tendon reconstruction. ACS Biomaterials Science and Engineering, 5, 1476-1486. 

22. C.S. Chang, S. Lin, C.G. Wallace, Y.C. Hsiao, C.M. Lin, G.C.W. Kang, Z.C. Chen, P.K.T. Chen, L.J. Lo, Y.R. Chen, J.P. Chen.* 2019. Masseter muscle volume changes evaluated  by 3-dimensional computed tomography after repeated botulinum toxin a injections in  patients with square facial morphology. Annals of Plastic Surgery, 82, S29-S32. 

23. G. Jose, Y.J. Lu, H.A. Chen, H.L. Hsu, J.T. Hung, Anilkumar T.S., J.P. Chen.* 2019.  Hyaluronic acid modified bubble-generating magnetic liposomes for targeted delivery of  doxorubicin. Journal of Magnetism and Magnetic Materials, 474, 355-364. 

24. M.N. Sundaram, S.D., U. Mony, K.T. Shalumon, J.P. Chen, R. Jayakumar. 2019. Chitosan  hydrogel scaffold reinforced with twisted poly(l-lactic acid) aligned microfibrous bundle  to mimic tendon extracellular matrix. International Journal of Biological Macromolecules, 122, 37-44. 

25. Anilkumar T.S., Y.J. Lu, H.A. Chen, H.L. Hsu, G. Jose, J.P. Chen.* 2019. Dual targeted  magnetic photosensitive liposomes for photothermal/photodynamic tumor therapy. Journal  of Magnetism and Magnetic Materials, 473, 241-252. 

26. G.C. Kang, Y.C. Hsiao, J.J. Huang, J.P. Chen, P.K. Chen, Y.R. Chen, C.S. Chang. 2019.  Aesthetic durable forehead contouring in asians with fat grafting and botulinum toxin.  Annals of Plastic Surgery, 82, S59-S65. 

27. H.T. Liao, M.J. Tsai, M. Brahmayya, J.P. Chen.* 2018. Bone regeneration using  adipose-derived stem cells in injectable thermo-gelling hydrogel scaffold containing  platelet-rich plasma and biphasic calcium phosphate. International Journal of Molecular  Sciences, 19:2537. 

28. K.T. Shalumon, C.Y. Kuo, C.B. Wong, Y.M. Chien, H.A. Chen, J.P. Chen.* 2018.  Gelatin/nanohyroxyapatite cryogel embedded poly(lactic-co-glycolic acid)/ nanohydroxyapatite microsphere hybrid scaffolds for simultaneous bone regeneration and  load-bearing. Polymers, 10:620. 

29. C.H. Chen, C.Y. Kuo, S.H. Chen, S.H. Mao, C.Y. Chang, K.T. Shalumon, J.P. Chen.* 2018. Thermosensitive injectable hydrogel for simultaneous intraperitoneal delivery of  doxorubicin and prevention of peritoneal adhesion. International Journal of Molecular  Sciences, 19:1373.

30. C.S. Chang, CG. Wallace, Y.C. Hsiao, J.J. Huang, Z.C. Chen, C.J. Chang, L.J. Lo, P.K.T.  Chen, J.P. Chen, Y.R. Chen. 2018. Clinical evaluation of silicone gel in the treatment of  cleft lip scars. Scientific Reports, 8:7422. 

31. K.T. Shalumon, C. Sheu, C.H. Chen, S.H. Chen, G. Jose, C.Y. Kuo, J.P. Chen.* 2018.  Multi-functional electrospun antibacterial core-shell nanofibrous membranes for  prolonged prevention of post-surgical tendon adhesion and inflammation. Acta  Biomaterialia, 72, 121-136. 

32. Y.J. Lu, P.Y. Lin, P.H. Huang, C.Y. Kuo, K.T. Shalumon, M.Y. Chen, J.P. Chen.* 2018.  Magnetic graphene oxide for dual targeted delivery of doxorubicin and photothermal  therapy. Nanomaterials, 8:193. 

33. K.T. Shalumon, J. Anjana, U. Mony, R. Jayakumar, J.P. Chen.* 2018. Process study,  development and degradation behavior of different size scale electrospun  poly(caprolactone) and poly(lactic acid) fibers. Journal of Polymer Research, 25:82. 

34. C.H. Chen, C.Y. Kuo, J.P. Chen.* 2018. Effect of cyclic dynamic compressive loading on  chondrocytes and adipose-derived stem cells co-cultured in highly elastic cryogel  scaffolds. Internartional Journal of Molecular Scieinces, 19:370 

35. C.S. Chang, C.G. Wallace, Y.C. Hsiao, T.C. Lu, S.H. Chen, F.C. Chan, P. K.T. Chen, J.P.  Chen, C.J. Chang and M. S. Noordhoff. 2017. Patient and parent reported outcome  measures in cleft lip and palate patients before and after secondary alveolar bone grafting.  Medicine, 96:52 

36. T.E. Lin, Y.J. Lu, C.L. Sun, H. Pick, J.P. Chen, A. Lesch, H.H. Girault. 2017. From tissues  to organs: soft electrochemical probes for mapping the distribution of biomarkers and  injected nanomaterials in animal and human tissues. Angewandte Chemie International  Edition, 56, 16498-16502. 

37. Y.T. Fong, C.H. Chen, J.P. Chen.* 2017. Intratumoral delivery of doxorubicin on  folate-conjugated graphene oxide by in-situ forming thermo-sensitive hydrogel for breast  cancer therapy. Nanomaterials, 7:388. 

38. P.Y. Chou, S.H. Chen, C.H. Chen, S.H. Chen, Y.T Fong, J.P. Chen.* 2017. Thermo-responsive in-situ forming hydrogels as barriers to prevent post-operative  peritendinous adhesion. Acta Biomaterialia, 63, 85-95.  

39. C.S. Chang,, C.G. Wallace, Y.C. Hsiao, Y.J. Hsieh, Y.C. Wang, N.H. Chen, Y.F. Liao,  E.J.W. Liou, P.K.T. Chen, J.P. Chen, Y.R. Chen. 2017. Airway changes after cleft  orthognathic surgery evaluated by three-dimensional computed tomography and overnight  polysomnographic study. Scientific Reports, 7:12260. 

40. C.H Chen, S.H. Chen, C.Y. Kuo, M.L. Li, J.P. Chen.* 2017. Response of dermal  fibroblasts to biochemical and physical cues in aligned polycaprolactone/silk fibroin  nanofiber scaffolds for application in tendon tissue engineering. Nanomaterials, 7:219. 

41. C.H. Chen, S.H. Chen, S.H. Mao, M.J. Tsai, P.Y. Chou, C.H. Liao, J.P. Chen.* 2017.  Injectable thermosensitive hydrogel containing hyaluronic acid and chitosan as a barrier  for prevention of postoperative peritoneal adhesion. Carbohydrate Polymers, 173,  721-731. 

42. C.L. Yang,#J.P. Chen,# K.C. Wei, J.Y. Chen, C.W. Huang, Z.X. Liao. 2017. Release of  doxorubicin by a folate-grafted, chitosan-coated magnetic nanoparticle. Nanomaterials,  7:85. 

43. S. Lin, Y.C. Hsiao, Y. C., J.J. Huang, C.S. Chang, P.K. Chen, J.P. Chen, L.J. Lo, Y.R. Chen.  2017. Minimal invasive rhinoplasty: fat injection for nasal dorsum contouring. Annals of  Plastic Surgery, 78, S117-S123. 

44. H.L. Hsu, J.P. Chen.* 2017. Preparation of thermosensitive magnetic liposome  encapsulated recombinant tissue plasminogen activator for targeted thrombolysis. Journal  of Magnetism and Magnetic Materials, 427, 188-194.  

45. Y.C. Lu, F.Y. Chang, S.J. Tu, J.P. Chen, Y.H. Ma. 2017. Cellular uptake of magnetite 

nanoparticles enhanced by NdFeB magnets in staggered arrangement. Journal of  Magnetism and Magnetic Materials, 427, 71-80. 

46. Y.S. Huang, Y.J. Lu, J.P. Chen.* 2017. Magnetic graphene oxide as a carrier for targeted  delivery of chemotherapy drugs in cancer therapy. Journal of Magnetism and Magnetic  Materials, 427, 34-40. 

47. K.T. Shalumon, C. Sheu, Y.T. Fong, H.T. Liao, J.P. Chen.* 2016. Microsphere-based  hierarchically juxtapositioned biphasic scaffolds prepared from poly(lactic-co-glycolic  acid) and nanohydroxyapatite for osteochondral tissue engineering. Polymers, 8:429. 

48. C.H. Chen, C.Y. Kuo, Y.J. Wang, J.P. Chen.* 2016. Dual function of glucosamine in  gelatin/hyaluronic acid cryogel to modulate scaffold mechanical properties and to  maintain chondrogenic phenotype for cartilage tissue engineering. International Journal of  Molecular Sciences, 17:1957. 

49. C. Sheu, K.T. Shalumon, C.H. Chen, C.Y. Kuo, Y.T. Fong, J.P. Chen.* 2016. Dual  crosslinked hyaluronic acid nanofibrous membranes for prolonged prevention of  post-surgical peritoneal adhesion. Journal of Materials Chemistry B, 4, 6680-6693.  

50. C.S. Chang, C.G. Wallace, Y.C. Hsiao, Y.T. Chiu, B.C.J. Pai, I.J. Chen, Y.F. Liao, E.J.W.  Liou, P.K.T. Chen, J.P. Chen, M.S. Noordhoff. 2016. Difference in the surgical outcome of  unilateral cleft lip and palate patients with and without pre-alveolar bone graft orthodontic  treatment. Scientific Reports, 6:23597. 

51. C.S. Chang, Y.C. Hsiao, J.J. Huang, J.P. Chen, P.K.T. Chen, G.C.W. Kang. 2016. Aesthetic  patient-centric approach to a unilateral zygomaticomaxillary fracture: computer-guided  osteotomy of the non-injured side. Aesthetic Surgery Journal, 36(5), NP184-NP186. 

52. J.P. Chen,* C.H. Liu, H.L. Hsu, T. Wu, Y.J. Lu, Y.H. Ma. 2016. Magnetically controlled  release of recombinant tissue plasminogen activator from chitosan nanocomposites for  targeted thrombolysis. Journal of Materials Chemistry B, 4, 25782590. 

53. H.T. Liao, K.T. Shalumon, K.H. Chang, C. Sheu, J.P. Chen.* 2016. Investigation of  synergistic effects of inductive and conductive factors in gelatin-based cryogels for bone  tissue engineering. Journal of Materials Chemistry B, 4, 1827-1841.