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長庚大學 化工與材料工程學系
Department of Chemical and Materials Engineering, Chang Gung University
劉繼賢 教授

劉繼賢 教授

Tel03-2118800 ext. 3146

細胞工程實驗室(工學大樓9)

E-mailchl@mail.cgu.edu.tw

Fax: 03-2118800 ext. 3140

 

學歷

清華大學               

化學工程研究所博士

1998-2001

大同工學院

化學工程研究所碩士

1990-1992

大同工學院

生物工程系學士

1986-1990

 

 

經歷

長庚大學長庚大學化工與材料工程學系

教授

2018/8-迄今

長庚大學生化生醫工程所

教授

2013-2018

長庚大學生化生醫工程所

教授兼所長

2013-2016

長庚大學生化生醫工程所

副教授

2007-2013

長庚大學生化生醫工程所

助理教授

2003-2007

食品工業發展研究所

研究員

2002-2003

懷德生技化學公司

生技處經理

2001-2002

美商安力達生技公司

專案經理

1998-2001

食品研究所

副研究員

1992-1998

 

 

 

研究領域

奈米技術之相關研究

生醫奈米微粒之製備與應用

載藥奈米微粒之藥物控制釋放

 

載藥奈米微粒之眼睛、皮膚傳遞

磁性奈米微粒之生化分離與基因傳遞

 

 

專業證照

環境工程技師

消防設備師

 

 

著作目錄

期刊論文

Rout, B., Liu, C. H.*, Wu, W. C. Increased anti-biofilm efficacy of toluidine blue on Staphylococcus species after nano-encapsulation. Photodiagnosis and Photodynamic Therapy, 2018, 21(3) 190–200, IF 2.219, Oncology 149/217 (Available online 13 December 2017)

Kumari, M., Liu, C. H.*, Wu, W. C. Efficient gene delivery by oligochitosan conjugated serum albumin: Facile synthesis, polyplex stability, and transfection, Carbohydrate Polymers, 2018, 183(3) 37-49, Chemistry, Applied, 4/72 (0.6%) (Available online 04 November 2017), IF 4.811,

 Hwang Y. S., Liu, C. H., Huang Y. C., Chen C. S., Chen T. L., Wang N. K., Chen Y. P., Chen K. J., Lai C. C., Wu W. C., 2017, Systemic effects after intravitreal injection of bevacizumab in new born rabbit eyes. Cutaneous and Ocular Toxicology, 7:1-11. IF1.213, Ophthalmology 47/59 (80%)

Ø     Liu, C. H., Lai, H.Y., Wu, W.C., 2017, Facile Synthesis of magnetic iron oxide nanoparticles for nattokinase isolation, Food and Bioproducts Processing, 102,260-267, IF 1.97, Food Science & Technology, 45/128 (35%) online 1 March 2017

Ø     Sahoo, S. L, Liu, C. H., Wu, W.C., 2017, Lymphoma cell isolation                            using multifunctional magnetic nanoparticles: antibody conjugation and          characterization. RCS Advances, 7, 2246822478.online 13 Apr 2017 IF              3.108, Chemistry, Multidisciplinary 59/165 (33%)

Ø     Rout, B., Liu, C. H., Wu, W. C. Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function, 2017, Scientific Reports, 7, Article number: 7892, doi: 10.1038/s41598-07444-w, Published online: 11 August 2017, 1F 4.259, Multidisciplinary Sciences 10/64 (16%).

Ø     Liu, C. H.*, Lai, H.Y., Wu, W.C., 2017, Facile Synthesis of magnetic iron oxide nanoparticles for nattokinase isolation, Food and Bioproducts Processing, Accepted.

Ø     Liu, C. H.*, Tsao, M.H., Sahoo, S. L, Wu, W. C. 2016, Magnetic nanoparticles with fluorescence and affinity for DNA sensing and nucleus staining, RSC Advances, DOI:10.1039/c6ra25610d, Accepted.

Ø     Liu, C. H.*, Lee, W.S., Wu, W. C. 2016, Photodynamic inactivation against Pseudomonas aeruginosa by curcumin microemulsions, RSC Advances, 6, 63013-63022.

Ø     Rout, B., Liu, C. H.*, Wu, W. C. 2016, Enhancement of photodynamic inactivation against Pseudomonas aeruginosa by a nano-carrier approach. Colloids and Surfaces B: Biointerfaces, 140:472-480.

Ø     Liu, C. H., Huang, Y. C., Jhang, J. W., Liu, Y. H., Wu, W. C., 2015 Quercetin delivery to porcine cornea and sclera by solid lipid nanoparticles and nanoemulsion, RSC Advances, 5, 100923 100933.

Ø     Sahoo, S. L, Liu, C. H., 2015, Adsorption behaviors of DNA by modified magnetic nanoparticles: Effect of spacer and salt, Colloids and Surfaces A: Physicochem. Eng. Aspects, 482, 184194.

Ø     Liu, C. H., Lai, K.Y., Wu, W.C., Chen,Y.J., Lee, W.S., Hsu, C.Y., 2015, In Vitro Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions, Chemical Pharmaceutical Bulletin, 63(2), 59-67

Ø   Liu, C. H., Sahoo, S.L. Tsao, M.H., 2014, Acridine orange coated magnetic nanoparticles for nucleus labeling and DNA adsorption, Colloids and Surfaces B: Biointerfaces, 115, 150-156

Ø   Wu, W C, Liu, C. H, Chen C. C., Wang, N.K., Chen, K.J., Chen T.L., Hwang, Y.S., Li, L.M., Lai, C.C., 2014, Lens subluxation after plasmin and SF6 injections in rabbit eyes, PLOS ONE,9 (11) e1129573.

Ø   Liu, C. H., Chiu, H.C., Wu, W.C., Sahoo, S.L., Hsu, C.Y., 2014,Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution, Journal of Ophthalmology, Volume 2014, Article ID 304694.

Ø   Liu, C. H., Sahoo, S.L. Tsao, M.H., 2014, Acridine orange coated magnetic nanoparticles for nucleus labeling and DNA adsorption, Colloids and Surfaces B: Biointerfaces, 115, 150-156

Ø   Chi Hsien Liu, Hao-Che Chiu, Wei-Chi Wu and Ching-Yun Hsu, Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution, Journal of Ophthalmology, Accepted

Ø   Hou, H.Y. Fu, S.H., Liu, C. H., Chen, J.P., Hsu, B.R.S., 2013, The graft survival protection of subcutaneous allogeneic islets with hydrogel grafting and encapsulated by CTLA4Ig and IL1ra, Polymer Journal, 46(2), 136-144.

Ø   Lin, L. T., Wang, B. S., Chen, J. C., Liu, C. H., Chou, Chiu, C., S. J., Chang, W. Y., Liu,R. S., Chang, C. A., Lee, Y. J., 2013, mPlum-IFP 1.4 fluorescent fusion protein may display Förster resonance energy transfer associated properties that can be used for near-infrared based reporter gene imaging. J. Biomed. Opt. 18(12), 126013

Ø   Liu, C. H., Huang H. Y. 2013, In vitro anti-Propionibacterium activity by curcumin containing vesicle system. Chemical Pharmaceutical Bulletin, 61(4): 419-425,

Ø   Liu, C. H., Wu, W.C., Lai, H. Y., 2013, Adsorption of nattokinase by amino acid-conjugated magnetic nanoadsorbents, Separation Science Technology, 48(6) 923-930

Ø   Liu, C. H., Hsien Y. F. 2013, Adsorption behaviors of nucleic acid by cationic magnetic nanoparticles, Applied Mechanics Materials, Vol. (284-287) 271-275 (EI, 其他)

Ø   Liu,C.H., Cheng M. S. 2013, Nanoparticles composed by oligochitosan and polyethylenimine for gene delivery, Applied Mechanics Materials, Vol. (284-287) 412-418 (EI, 其他)

Ø   Liu, C. H., Huang H. Y. 2013, In vitro anti-Propionibacterium activity by curcumin containing vesicle system. Chemical Pharmaceutical Bulletin, 61(4): 419-425 (SCI)

Ø   Liu, C. H., Wu, W.C., Lai, H. Y., 2013, Adsorption of nattokinase by amino acid-conjugated magnetic nanoadsorbents, Separation Science Technology, 48(6) 923-930 (SCI)

Ø   Liu, C. H., Huang H. Y., 2012, Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis, Chemical Pharmaceutical Bulletin (1.657, 170/261) 60(9):1118-24

Ø   Wu, W C, Liu, C. H., Chen C. C., et al., 2012, Efficient vitreolysis by combining plasmin and sulfur hexafluoride injection in a preclinical study in rabbit eyes, Molecular Vision, 18:2361-2370

Ø   Liu, C. H., Wu, W.C.,Lai, H. Y., Hou, H. Y., 2011, Magnetic purification of plasminogen from human plasma by specific lysine affinity, J. Bioscience and Bioengineering 112(3):219-24.,

Ø   Liu, C. H., Chang, F.Y., 2011, Development and characterization of eucalyptol microemulsions for topic delivery of curcumin, Chem Pharm Bull., 59(2):172-8.

Ø   Wu, W.C., Chen, C.C., Liu, C. H., Wang, N.K., Chen, K.J., Chen T.L., Hwang, Y.S., Li, L.M., Lai, C.C., 2011, Plasmin treatment accelerates vascular endothelial growth factor clearance from rabbit eyes. Invest Ophthalmol Vis Sci.52(9),6162-7.

Ø   Liu, C. H., Chang, F. Y., Hung, D.-K., 2011, Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants, Colloids and Surfaces B: Biointerfaces, 82, 6370

Ø   Peng, L.C., Liu, C. H., Kwan, C.C., Huang, K.F., 2010, Optimization of water-in-oil nanoemulsions by mixed surfactants Colloids and Surfaces A: Physicochemical and Engineering Aspects, 370, 136142

Ø   Liu, C. H., Yu, S. Y., 2010, Cationic nanoemulsions as non-viral vectors for plasmid DNA delivery, Colloids and Surfaces B: Biointerfaces, 79(2) 509-515.

Ø   Liu, C. H., Wu, C. T., 2010, Optimization of nanostructured lipid carriers for lutein delivery, Colloids and Surfaces A: Physicochem. Eng. Spects, 353(2-3) 149-156.

Ø   Liu, C. H., Wu, C. T., Fang, J. Y., 2010, Characterization and formulation optimization of solid lipid nanoparticles in vitamin K1 delivery, Drug Development and Industrial Pharmacy, 2010, 36(7), 751-761.

Ø   Liu, C. H., Wu, K. W. Synergistic effects of basic fibroblast growth factor and insulin on Chinese hamster ovary cells under serum-free conditions, 2009, J. Bioscience and Bioengineering, 107(3), 312-317.

國際研討會論文

Ø   Tsao, M.H., Sahoo, S.L., Liu, C.H., DNA staining nanoparticles for nucleus imaging, 2016 Society for Biotechnology Japan, Toyama, Japan, 2016, Sep 28-Oct 2.

Ø   Lee, W.S. Rout, B., Liu, C.H., Photodynamic antibacterial activity of curcumin by nano-lipid vehicles, 2015 Society for Biotechnology Japan, Kagoshima, Japan, 2015, Oct 26-28.

Ø   Rout, B., Liu, C.H., Photodynamic antibacterial effect of Toluidine Blue O and EDTA in a microemulsion delivery system, Symposium of Young Asian Biochemical Engineers Community, Chuncheon, Korea, 2015, Oct 15-16.

Ø   Chen Y.J., Liu, C.H., Polyphenol ocular delivery by nanocarriers. Symposium of Young Asian Biochemical Engineers Community 2015, Chuncheon, Korea, 2015, Oct15-16.

Ø   Chi-Hsien Liu, Yu-Jui Chen, Yun-Chun Huang, Antioxidation and ocular delivery of quercetin laden lipid nanocarriers, 2014 annual meeting of the Society for Biotechnology, Japan. Sep, 9-11, 2014.

Ø   Chi-Hsien Liu, Min Han Tsao, Functional iron nanoparticles for cell labeling and    DNA separation, 2013 annual meeting of the Society for Biotechnology, Japan. Sep, 18-20, 2013.

Ø   Yu DS , Tsao SW and Hsu FY. Fabrication and characterization of Eudragit S100-coatedpectin/alginate microcapsules containing cisplatin-hyaluronan nanoparticles for colon targeted delivery. 40th Annual Meeting & Exposition of the Controlled Release Society, July. 2013, Hawaii, America

 

專利與成果

劉繼賢,賴宣余,吳為吉, 磁性粒子純化血液酵素, 中華民國專利申請中

 

劉繼賢,廖啟成, 2000 , 生產紅茶菇飲料之菌株及其用於發酵製備紅茶菇飲料之方法(日本國專利特許第3084348) (中華民國專利編號385335)

 

Optimizing culture medium for CD34+ hematopoietic cell expansion. 2014,

專利號碼: US 8,762,074 B2 發明人:黃效民、劉繼賢、姚少凌、朱一民、謝祖柏