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Department of Chemical and Materials Engineering

Chi-Hsien Liu

Chi-Hsien Liu

 
 

 

Chi-Hsien Liu, Professor 

Education: PhD. of Chemical Engineering; National Tsing

Hua   University,Taiwan

Interests:  Stem cell technology, Nanotechnology,

Drug delivery, Biochemical engineering

Telephone: 886-3-2118800 Ext: 3146

E-mail: chl@mail.cgu.edu.tw   

Laboratory: Cell Engineering Lab

 

 EDUCATION

09/1998-06/2001      Ph.D. in Chemical Engineering; National Tsing Hua University, Taiwan

09/1990-06/1992      M.S. in Chemical Engineering; Tatung University , Taiwan

09/1986-06/1990       B.S. in Bio Engineering; Tatung University , Taiwan

 

PROFESSIONAL EXPERIENCE 

08/2018-present  Professor, Department Chemical and Materials Engineering ; Chang Gung University, Taiwan

08/2013-07/2018  Professor, Institute of Biochemical and Biomedical Engineering; Chang Gung University, Taiwan

08/2013-07/2016  Director, Institute of Biochemical and Biomedical Engineering; Chang Gung University, Taiwan

08/2007-07/2013   Associate Professor, Institute of Biochemical and Biomedical Engineering; Chang Gung University, Taiwan

08/2003-07/2007   Assistant Professor, Institute of Biochemical and Biomedical Engineering; Chang Gung University, Taiwan

08/2002-07/2003   Scientist Fellow, Food Industry Research Development Institute (FIRDI)

10/2001-07/2002   R&D manager, Widex Biotech. Co.

04/2001-09/2001   Project manager, Analytica Biotech. Co.

08/1992-08/1998  Associate Scientist Fellow, FIRDI

 

RESEARCH INTERESTS 

Drug delivery

Stem cell technology

Biochemical engineering

Nanotechnology

 

 PROFESSIONAL AFFILIATIONS

Member, Biochemical Engineering Society of Taiwan (BEST)

Member, Biomedical Engineering Society of ROC

Overseas Member, Society for Biotechnology, Japan

 

 PROFESSIONAL RESPONSIBILITIES

Journal Reviewer, Biochemical Engineering Journal

Journal Reviewer, Process Biochemistry

Journal Reviewer, Cytotherapy

Journal Reviewer, International Journal of Pharmaceutics

Journal Reviewer, Journal of the Chinese Institute of Chemical Engineers

Conference Reviewer, Annual Symposium of the Biochemical Engineering Society of Taiwan

 

 AWARDS AND HONORS

Special contribution Award for FIRDI; (1998)

Program Execution Award from Ministry of Economic Affairs (1998)

 

 BIBLIOGRAPHY

  1. PEER-REVIEWED PUBLICATIONS (*Corresponding Author)

Ø Liu, C. H.*, Liu, Y. X., Wu, W. C. Facile development of medium optimization for antibody production: Implementation in spinner flask and hollow fiber reactor, Cytotechnology, accepted, Biotechnology & Applied Microbiology, 119/160 (74 %) (Available online 04 November 2018), IF 1.461,

Ø Kumari, M., Liu, C. H.*, Wu, W. C. Protein moiety in oligochitosan modified vector regulates internalization mechanism and gene delivery: Polyplex characterization, intracellular trafficking and transfection. Carbohydrate Polymers, 2018, 202, 143-156 Chemistry, Applied, 2/71 (3 %) (Available online 31 August 2018), IF 5.158,

Ø Rout, B., Liu, C. H.*, Wu, W. C. Increased anti-biofilm efficacy of toluidine blue on Staphylococcus species after nano-encapsulation. Photodiagnosis and Photodynamic Therapy, 2018, 21(3) 190–200, IF 2.895, Oncology 127/222 (Available online 13 December 2017)

Ø Kumari, M., Liu, C. H.*, Wu, W. C. Efficient gene delivery by oligochitosan conjugated serum albumin: Facile synthesis, polyplex stability, and transfection, Carbohydrate Polymers, 2018, 183(3) 37-49, Chemistry, Applied, 2/71 (3%) (Available online 04 November 2017), IF 5.158,

Ø Hwang Y. S., Liu, C. H.*, Huang Y. C., Chen C. S., Chen T. L., Wang N. K., Chen Y. P., Chen K. J., Lai C. C., Wu W. C., 2017, Systemic effects after intravitreal injection of bevacizumab in new born rabbit eyes. Cutaneous and Ocular Toxicology, 7:1-11. IF1.213, Ophthalmology 47/59 (80%)

ØSahoo, S. L, Liu, C. H.*, Wu, W.C., 2017, Lymphoma cell isolation using multifunctional magnetic nanoparticles: antibody conjugation and characterization. RCS Advances, 7, 22468–22478.online 13 Apr 2017 IF 3.108, Chemistry, Multidisciplinary 59/165 (33%)

ØRout, B., Liu, C. H.*, Wu, W. C. Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function, 2017, Scientific Reports, 7, Article number: 7892, doi:10.1038/s41598-017-07444-w, Published online: 11 August 2017, IF 4.259, Multidisciplinary Sciences 10/64 (16%)

ØLiu, C. H.*, Lai, H.Y., Wu, W.C., 2017, Facile Synthesis of magnetic iron oxide nanoparticles for nattokinase isolation, Food and Bioproducts Processing, Accepted.

ØLiu, C. H.*, Tsao, M.H., Sahoo, S. L, Wu, W. C. 2016, Magnetic nanoparticles with fluorescence and affinity for DNA sensing and nucleus staining, RSC Advances,DOI:10.1039/c6ra25610d, Accepted.

ØLiu, C. H.*, Lee, W.S., Wu, W. C. 2016, Photodynamic inactivation against Pseudomonas aeruginosa by curcumin microemulsions, RSC Advances, 6, 63013-63022.

ØRout, B., Liu, C. H.*, Wu, W. C. 2016, Enhancement of photodynamic inactivation against Pseudomonas aeruginosa by a nano-carrier approach. Colloids and Surfaces B: Biointerfaces, 140:472-480. 

ØLiu, C. H., Huang, Y. C., Jhang, J. W., Liu, Y. H., Wu, W. C., 2015 Quercetin delivery to porcine cornea and sclera by solid lipid nanoparticles and nanoemulsion, RSC Advances, 5, 100923 – 100933.

ØSahoo, S. L, Liu, C. H., 2015, Adsorption behaviors of DNA by modified magnetic nanoparticles: Effect of spacer and salt, Colloids and Surfaces A: Physicochem. Eng. Aspects, 482, 184–194.

ØLiu, C. H., Lai, K.Y., Wu, W.C., Chen,Y.J., Lee, W.S., Hsu, C.Y., 2015, In Vitro Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions, Chemical Pharmaceutical Bulletin, 63(2), 59-67.

Ø Liu, C. H., Sahoo, S.L. Tsao, M.H., 2014, Acridine orange coated magnetic nanoparticles for nucleus labeling and DNA adsorption, Colloids and Surfaces B: Biointerfaces, 115, 150-156

Ø Wu, W C, Liu, C. H, Chen C. C., Wang, N.K., Chen, K.J., Chen T.L., Hwang, Y.S., Li, L.M., Lai, C.C., 2014, Lens subluxation after plasmin and SF6 injections in rabbit eyes, PLOS ONE,9 (11) e1129573.

Ø Liu, C. H., Chiu, H.C., Wu, W.C., Sahoo, S.L., Hsu, C.Y., 2014,Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution, Journal of Ophthalmology, Volume 2014, Article ID 304694.

Ø Liu, C. H., Sahoo, S.L. Tsao, M.H., 2014, Acridine orange coated magnetic nanoparticles for nucleus labeling and DNA adsorption, Colloids and Surfaces B: Biointerfaces, 115, 150-156

Ø Chi Hsien Liu, Hao-Che Chiu, Wei-Chi Wu and Ching-Yun Hsu, Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution, Journal of Ophthalmology, Accepted

Ø Hou, H.Y. Fu, S.H., Liu, C.H., Chen, J.P., Hsu, B.R.S., 2013, The graft survival protection of subcutaneous allogeneic islets with hydrogel grafting and encapsulated by CTLA4Ig and IL1ra, Polymer Journal, 46(2), 136-144.

Ø Lin, L. T., Wang, B. S., Chen, J. C., Liu, C. H., Chou, Chiu, C., S. J., Chang, W. Y., Liu,R. S., Chang, C. A., Lee, Y. J., 2013, mPlum-IFP 1.4 fluorescent fusion protein may display Förster resonance energy transfer associated properties that can be used for near-infrared based reporter gene imaging. J. Biomed. Opt. 18(12), 126013

Ø Liu, C. H., Huang H. Y. 2013, In vitro anti-Propionibacterium activity by curcumin containing vesicle system. Chemical Pharmaceutical Bulletin, 61(4): 419-425,

Ø Liu,C.H., Wu, W.C., Lai, H. Y., 2013, Adsorption of nattokinase by amino acid-conjugated magnetic nanoadsorbents, Separation Science Technology, 48(6) 923-930

Ø Liu,C.H., Hsien Y. F. 2013, Adsorption behaviors of nucleic acid by cationic magnetic nanoparticles, Applied Mechanics Materials, Vol. (284-287) 271-275 (EI, 其他)

Ø Liu,C.H., Cheng M. S. 2013, Nanoparticles composed by oligochitosan and polyethylenimine for gene delivery, Applied Mechanics Materials, Vol. (284-287) 412-418 (EI, 其他)

Ø Liu, C. H., Huang H. Y. 2013, In vitro anti-Propionibacterium activity by curcumin containing vesicle system. Chemical Pharmaceutical Bulletin, 61(4): 419-425 (SCI)

Ø Liu, C. H., Wu, W.C., Lai, H. Y., 2013, Adsorption of nattokinase by amino acid-conjugated magnetic nanoadsorbents, Separation Science Technology, 48(6) 923-930 (SCI)

Ø Liu, C. H., Huang H. Y., 2012, Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis, Chemical Pharmaceutical Bulletin (1.657, 170/261) 60(9):1118-24

Ø Wu, W C, Liu, C. H., Chen C. C., et al., 2012, Efficient vitreolysis by combining plasmin and sulfur hexafluoride injection in a preclinical study in rabbit eyes, Molecular Vision, 18:2361-2370

Ø Liu, C. H., Wu, W.C.,Lai, H. Y., Hou, H. Y., 2011, Magnetic purification of plasminogen from human plasma by specific lysine affinity, J. Bioscience and Bioengineering 112(3):219-24.,

Ø Liu, C. H., Chang, F.Y., 2011, Development and characterization of eucalyptol microemulsions for topic delivery of curcumin, Chem Pharm Bull., 59(2):172-8.

Ø Wu, W.C., Chen, C.C., Liu, C. H., Wang, N.K., Chen, K.J., Chen T.L., Hwang, Y.S., Li, L.M., Lai, C.C., 2011, Plasmin treatment accelerates vascular endothelial growth factor clearance from rabbit eyes. Invest Ophthalmol Vis Sci.52(9),6162-7.

Ø Liu, C. H., Chang, F. Y., Hung, D.-K., 2011, Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants, Colloids and Surfaces B: Biointerfaces, 82, 63–70

Ø Peng, L.C., Liu, C. H., Kwan, C.C., Huang, K.F., 2010, Optimization of water-in-oil nanoemulsions by mixed surfactants Colloids and Surfaces A: Physicochemical and Engineering Aspects, 370, 136–142

Ø Liu, C. H., Yu, S. Y., 2010, Cationic nanoemulsions as non-viral vectors for plasmid DNA delivery, Colloids and Surfaces B: Biointerfaces, 79(2) 509-515.

Ø Liu, C. H., Wu, C. T., 2010, Optimization of nanostructured lipid carriers for lutein delivery, Colloids and Surfaces A: Physicochem. Eng. Spects, 353(2-3) 149-156.

Ø Liu, C. H., Wu, C. T., Fang, J. Y., 2010, Characterization and formulation optimization of solid lipid nanoparticles in vitamin K1 delivery, Drug Development and Industrial Pharmacy, 2010, 36(7), 751-761.

Ø Liu, C. H., Wu, K. W. Synergistic effects of basic fibroblast growth factor and insulin on Chinese hamster ovary cells under serum-free conditions, 2009, J. Bioscience and Bioengineering, 107(3), 312-317.

(B) BOOK CHAPTERS AND MONOGRAPHS

Liu, C. H., Hwang, S. M., Serum-free cell culture system, In: First Mr. Hsieh Memorial Award  Proceeding. p201-228, 2004

(C) CONFERENCE PRESENTATIONS

1. Liu, C. H., Wen, C. C., Benzyl alcohol and its esters enhance recombinant 

    protein expression in Chinese hamster ovary cells, Annual meeting of the

    Society for Biotechnology, Nagoya University. Higashiyama Campus,

    September 23-25,2009

2. Liu, C. H., Chang, K H, Molecular cloning and characterization of a  

    thermostable lipase from plant Carica papaya. Annual meeting of the

    Society for Biotechnology, Japan. Tohoku Gakuin University,August 27-29,

    2008 

(D) PATENTS

Liu, C. H., Liao, C. C. 2000, Microorganisms and process for fermented black tea beverage (Japan Patent 3084348 ; ROC Patent 385335)