Your browser does not support JavaScript!
長庚大學 化工與材料工程學系
Department of Chemical and Materials Engineering, Chang Gung University
蔡少偉 教授

蔡少偉 教授

Tel03-2118800 ext. 3415

生物反應器工程實驗室(工學大樓9) ext. 3412

E-mailtsai@mail.cgu.edu.tw

Fax: 03-2118800 ext. 3140

 

經歷

長庚大學化工與材料工程學系

教授

2018/08-迄今

長庚大學生化與生醫工程研究所

教授     

2005/08-2018/07

長庚大學生化與生醫工程研究所  

所長

2006/08-2013/07

司圖加大學熱力與熱程工程研究所

訪問教授

2004/08-2004/10  

成功大學工學院

副院長

2002/09-2004/07  

成功大學化學工程學系  

系主任

1997/08-1999/07

成功大學教務處學服組

主任

1990/08-1993/07  

愛荷華大學化學及生化工程學系

訪問教授

1994/02-1995/01  

成功大學化學工程學系

教授

1989/08-2005/07

成功大學化學工程學系

副教授

1985/06-1989/07

麻省理工學院化學工程學系

訪問學者

1987/09-1988/06

成功大學化學工程學系

講師

1982/08-1985/05

 

學歷

成功大學     

化工博士

1982-1985

成功大學      

化工碩士

1977-1979

清華大學   

化工學士

1973-1977

       

 

專長

酵素工程、化學反應器工程、單元操作

 

主要研究領域

1. 酵素於有機合成應用
 
利用酵素之基質、位置、立體特異性催化能力,以製備高光學純度鏡像異構藥物及其中間體為目標,進行酵素(動態)動力分割製程開發。

2. 化學反應器工程
 
以酵素(動態)動力分割製程為對象,建立各種鏡像異構藥物及其中間體知動力學模式,以期作為化學反應器設計與操作依據。

 

論文及專利

(A) 期刊論文(2011後)

 

  1. Yeh, Y. R., Tzeng, Y. J. Tsai, S. W. 2018. Quantitative Improvements and Insights into CALB-Catalyzed Resolution of trans- and cis-2-Phenylcyclopropyl Azolides, ChemistrySelect 3, 5353-5360.
  2. Wu, T. Y., Lai, Y. R., Tsai, S. W. 2018. CALB-catalyzed two-step alcoholytic desymmetrization of 3-methylglutaric diazolides in MTBE, Appl. Biochem. Biotechnol. 185, 578-592.
  3. Hsu, C. H., Tsai, S. W. 2017. Lipase-catalysed two-step desymmetrization of 2-methylmalonic dipyrazolide for preparation of optically pure enantiomer in organic solvents, Biocat. Biotrans. 35, 460-467.
  4. Tsai, S. W. 2017. Quantitative insights into one-pot sequential asymmetric enzymatic catalytic processes, JTIChE, 74, 79-88. 
  5. Lee, I. C., Wu, Y. C., Tsai, S. W., Chen, C. H., Wu, M. H. 2017. Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for: In vivo insulin transdermal delivery. RSC Advances, 7, 5067-5075.
  6. Lee, I. C., Lin, W. M., Shu, J. C., Tsai, S. W., Chen, C. H., Tsai, M. T. 2017. Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice J. Biomed. Mater. Research, Part A, 7, 5067-5075.
  7. Lee, M. T., Lee, I. C., Tsai, S. W., Chen, C. H., Wu, M. H., Juang, Y. J. 2017. Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch, JTIChE, 70, 42-48.
  8. Tsai, S. W., 2016. Enantiopreference of Candida antarctica lipase B toward carboxylic acids: substrate models and enantioselectivity thereof, J. Mol. Cat. B: Enzymatic, 127, 98-116.
  9. H. T. Hsiao, Lin, S. Y. Tsai, S. W. 2016. Quantitative insights and improvements of enzyme activity and stereoselectivity for CALB-catalyzed alcoholysis in two-step desymmetrization, J. Mol. Cat. B: Enzymatic, 127, 82-88.
  10. Kao, J. Y., Tsai, S. W. 2016. Kinetic analysis for lipase-catalyzed regioselective methanolysis of (R)- and (S)-2-methylglutaric dipyrazolides for preparation of (R)-methyl 2-methyl-5-oxo-5-[1H-pyrazol-1-yl)pentanoate and (S)-methyl 4-methyl-5-oxo-5-[1H-pyrazol-1-yl)pentanoate, JTIChE, 59, 120-125.
  11. Chan, P. H., Tsai, S. W. 2016. Two-step desymmetrization of dipyrazolidyl 3-phenylglutarate via lipase-catalyzed hydrolysis in organic solvents, Chem. Eng. Sci., 139, 41-48.
  12. Ko, P. T. Lee, I. C. Chen, M. C. Tsai, S. W. 2015. Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds, JTIChE, 51, 1-8.
  13. Huang, Y. K. Tsai, S. W., 2014. Kinetic and thermodynamic analysis of Candida antarctica lipase B-catalyzed alcoholytic resolution of (R,S)-β-butyrolactone in organic solvents, App. Microb. Biotechnol., 98, 621-628.
  14. Wu, C. H., Wang, P. Y., Tsai, S. W., 2013. Kinetic analysis for lipase-catalyzed hydrolysis of (R,S)-1,2,4-triazolides derived from N-Cbz-proline and (R,S)-N-Cbz-pipecolic acid, JTIChE, 44, 146-151.
  15. Wu, C. H., Pen, C. W., Wang, P. Y., Tsai, S. W., 2013. An efficient lipase-catalyzed enantioselective hydrolysis of (R,S)-azolides derived from N-protected proline, pipecolic acid, and nipecotic acid, App. Microb. Biotechnol. 97, 1581-1587.
  16. Cheng, Y. L.,   Wu, C. H., Wang, P. Y., Tsai, S. W. 2012. Kinetic and thermodynamic analysis for lipase-catalyzed hydrolytic resolution of (R,S)-alcohols though their azolyl carbamates, Biopro. Biosys. Eng.35, 953-962.
  17. Chen, J. R., Wu, C. H., Wang, P. Y., Tsai, S. W. 2012. Kinetic and thermodynamic investigation of lipase-catalyzed hydrolysis of (R,S)-3-phenylbutyl azolides, IEC Research 51, 3580-3586.
  18. Kao, M. F., Lu, P. Y., Kao, J. Y., Wang, P. Y., Wu, A. C., Tsai, S. W., 2012. (R,S)-2-Chlorophenoxyl pyrazolides as extreme substrates for improving lipase-catalyzed hydrolytic resolution, Chirality 24, 60-66.
  19. Wu, A. C., Wang, P. Y., Tsai, S. W., 2012. Lipase-catalyzed regioselective hydrolysis of 3(5)-methylpyrazole-N-carboxylates in water-saturated organic solvents, J. Mol. Cat. B: Enzymatic, 74, 41-47.
  20. Cho, S. H., Wang, P. Y., Tsai, S. W., 2011. Lipase-catalyzed hydrolytic resolution of (R,S)-3-hydroxy-3-phenylpropionates in biphasic media,” JTIChE 42, 408-412.
  21. Ciou, J. F., Wang, P. Y., Wu, A. C., Tsai, S. W., 2011. Lipase-catalyzed alcoholytic resolution of (R,S)-flurbiprofenyl azolides for preparation of (R)-NO-flurbiprofen ester prodrugs, Proc. Biochem. 46, 960-965.
  22. Lin, Y. S., Wang, P. Y., Wu, A. C., Tsai, S. W., 2011. Lipase-catalyzed enantioselective resolution of (R,S)-N-2-methylalkanoyl-3-(2-pyridyl)pyrazoles in organic solvents, J. Mol. Cat. B: Enzymatic, 68, 245-249.

 

(B) 專利

 

1.   蔡少偉、王培筠,2013,酵素動力分割方法,中華民國專利I388667號(有效期   2013/03/11-2029/08/20)。

2.   Tsai, S. W. and Wang P. Y. 2013. Method for producing an optically active compound, US Patent 8377660.

3.   Tsai, S. W. 2009, Enzymatic resolution of an alpha-substituted carboxylic acid or   an ester thereof by Carica papaya lipase, Japan Patent 4247545

4.   蔡少徫,2007,以木瓜脂肪分解酵素進行α-取代基酸或其酯類化合物之動力分割的方法,中華民國專利I276687號,(有效期 2007/03/21 -2024/06/29)

5.  蔡少偉、張春生,2002,光學活性S形2-芳香取代基丙酸((S)-profens)或其S形酯類之製造方法,中華民國專利150558號。

6.  Tsai, S. W. and Chang C. S. 2001. Processes for preparing optically active (S)-a-aryl propionic acid or ester thereof, US Patent 6201151.