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Department of Chemical and Materials Engineering

Shau-Wei Tsai

Shau-Wei TsaiProfessor

Education:  PhD. of Engineering in Chemical Engineering National Cheng   Kung University, TAIWAN

Interests: Biocatalysis, Bioseparation, Reaction Engineering

Telephone: 886-3-2118800 Ext: 3415

E-mail: tsai@mail.cgu.edu.tw

Laboratory:  Bioreactor engineering Lab 

 
Education

 

Dr. of Engineering, 1985, National Cheng Kung University, Taiwan

MS, 1979, National Cheng Kung University, Taiwan

BS, 1977, National Tsing Hua University, Taiwan

 
Publications
 

Referred papers (since 2011)

Ø   Wang, X. Y., Liu, J. X., Tsai, S. W. 2019. “Lipase-catalyzed hydrolytic resolution of trans -2-(3,4-difluorophenyl)cyclopropyl azolides, a key building block for Ticagrelor synthesis”, JTIChE, 97, 112-118.

Ø   Yeh, Y. R., Tzeng, Y. J. Tsai, S. W. 2018. “Quantitative improvements and insights into CALB-catalyzed resolution of trans- and cis-2-phenylcyclopropyl azolides”, ChemistrySelect 3, 5353-5360.

Ø     Wu, T. Y., Lai, Y. R., Tsai, S. W. 2018. “CALB-catalyzed two-step alcoholytic desymmetrization of 3-methylglutaric diazolides in MTBE”, Appl. Biochem. Biotechnol. 185, 578-592.

Ø    Lee, M. T., Lee, I. C., Tsai, S. W., Chen, C. H., Wu, M. H., Juang, Y. J. 2017. “Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch”, JTIChE, 70, 42-48. 

Ø    Lee, I. C., Lin, W. M., Shu, J. C., Tsai, S. W., Chen, C. H., Tsai, M. T. 2017. “Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice”, J. Biomed. Mater. Research, Part A, 7, 5067-5075.

Ø    Lee, I. C., Wu, Y. C., Tsai, S. W., Chen, C. H., Wu, M. H. 2017. “Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for: In vivo insulin transdermal delivery“, RSC Advances, 7, 5067-5075.

Ø     Tsai, S. W. 2017. “Quantitative insights into one-pot sequential asymmetric enzymatic catalytic processes”, JTIChE, 74, 79-88.

Ø     Hsu, C. H., Tsai, S. W. 2017. “Lipase-catalysed two-step desymmetrization of 2-methylmalonic dipyrazolide for preparation of optically pure enantiomer in organic solvents“ , Biocat. Biotrans. 35, 460-467.

Ø  Kao, J. Y., Tsai, S. W. 2016 “Kinetic analysis for lipase-catalyzed regioselective methanolysis of (R)- and (S)-2-methylglutaric dipyrazolides for preparation of (R)-methyl 2-methyl-5-oxo-

5-[1H-pyrazol-1-yl)pentanoate and (S)-methyl 4-methyl-5-oxo-5-[1H- pyrazol-1-yl)pentanoate”, JTIChE, 59, 120-125.

Ø  Tsai, S. W., 2016. “Enantiopreference of Candida antarctica lipase B toward carboxylic acids: substrate models and enantioselectivity thereof”, J. Mol. Cat. B: Enzymatic, 127, 98-116.

Ø  Hsiao, H. T. Lin, S. Y. Tsai, S. W. 2016. “Quantitative insights and

Improvements of enzyme activity and stereoselectivity for CALB-catalyzed alcoholysis in two-step desymmetrization,” J. Mol. Cat. B: Enzymatic, 127, 82-88.

Ø  Chan, P. H., Tsai, S. W. 2016. “Two-step desymmetrization of dipyrazolidyl 3-phenylglutarate via lipase-catalyzed hydrolysis in organic solvents,” Chem. Eng. Sci., 139, 41-48.

Ø   Ko, P. T. Lee, I. C. Chen, M. C. Tsai, S. W. 2015. “Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds”, JTIChE, 51, 1-8.

Ø  Huang, Y. K. Tsai, S. W., 2014. “Kinetic and thermodynamic analysis of Candida antarctica lipase B-catalyzed alcoholytic resolution of (R,S)-β-butyrolactone in organic solvents”, App. Microb. Biotechnol., 98, 621-628.

Ø  Wu, C. H., Wang, P. Y., Tsai, S. W., 2013. “Kinetic analysis for lipase-catalyzed hydrolysis of (R,S)-1,2,4-triazolides derived from N-Cbz-proline and (R,S)-N-Cbz-pipecolic acid”, JTIChE, 44, 146-151.

Ø   Wu, C. H., Pen, C. W., Wang, P. Y., Tsai, S. W., 2013. “An efficient lipase-catalyzed enantioselective hydrolysis of (R,S)-azolides derived from N-protected proline, pipecolic acid, and nipecotic acid”, App. Microb. Biotechnol. 97, 1581-1587.

Ø  Cheng, Y. L.,   Wu, C. H., Wang, P. Y., Tsai, S. W. 2012. “Kinetic and thermodynamic analysis for lipase-catalyzed hydrolytic resolution of (R,S)-alcohols though their azolyl carbamates”, Biopro. Biosys. Eng.35, 953-962.

Ø   Chen, J. R., Wu, C. H., Wang, P. Y., Tsai, S. W. 2012. “Kinetic and thermodynamic investigation of lipase-catalyzed hydrolysis of (R,S)-3-phenylbutyl azolides” , IEC Research 51, 3580-3586.

Ø  Kao, M. F., Lu, P. Y., Kao, J. Y., Wang, P. Y., Wu, A. C., Tsai, S. W., 2012. “(R,S)-2-Chlorophenoxyl pyrazolides as extreme substrates for improving lipase-catalyzed hydrolytic resolution”, Chirality 24, 60-66.

Ø   Wu, A. C., Wang, P. Y., Tsai, S. W., 2012. “Lipase-catalyzed regioselective hydrolysis of 3(5)-methylpyrazole-N-carboxylates in water-saturated organic solvents”, J. Mol. Cat. B: Enzymatic, 74, 41-47.

Ø  Cho, S. H., Wang, P. Y., Tsai, S. W., 2011. “Lipase-catalyzed hydrolytic resolution of (R,S)-3-hydroxy-3-phenylpropionates in biphasic media”, JTIChE 42, 408-412.

Ø   Ciou, J. F., Wang, P. Y., Wu, A. C., Tsai, S. W., 2011. “Lipase-catalyzed alcoholytic resolution of (R,S)-flurbiprofenyl azolides for preparation of (R)-NO-flurbiprofen ester prodrugs,” Proc. Biochem. 46, 960-965.

Ø  Lin, Y. S., Wang, P. Y., Wu, A. C., Tsai, S. W., 2011. “Lipase-catalyzed enantioselective resolution of (R,S)-N-2-methylalkanoyl-3-

(2-pyridyl)pyrazoles in organic solvents”, J. Mol. Cat. B: Enzymatic, 68, 245-249.

Patents

Ø  Tsai, S. W. and Wang P. Y. Method for producing an optically active compound”, US Patent 8377660 (2013); ROC Patent 1388667 (2013).

Ø  Tsai, S. W. “Enzymatic resolution of an alpha-substituted carboxylic acid or an ester thereof by Carica papaya lipase”, Japan Patent 4247545 (2009); ROC Patent 276687 (2007).

Ø  Tsai, S. W. and Chang C. S. “Processes for preparing optically active (S)-a-aryl propionic acid or ester thereof,” US Patent 6201151 (2001); ROC Patent 150558 (2002).