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Department of Chemical and Materials Engineering

Shau-Wei Tsai

Shau-Wei TsaiProfessor

Education:  PhD. of Engineering in Chemical Engineering National Cheng   Kung University, TAIWAN

Interests: Biocatalysis, Bioseparation, Reaction Engineering

Telephone: 886-3-2118800 Ext: 3415

E-mail: tsai@mail.cgu.edu.tw

Laboratory:  Bioreactor engineering Lab 



Dr. of Engineering, 1985, National Cheng Kung University, Taiwan

MS, 1979, National Cheng Kung University, Taiwan

BS, 1977, National Tsing Hua University, Taiwan


Referred papers (since 2011)

Ø   Wang, X. Y., Liu, J. X., Tsai, S. W. 2019. “Lipase-catalyzed hydrolytic resolution of trans -2-(3,4-difluorophenyl)cyclopropyl azolides, a key building block for Ticagrelor synthesis”, JTIChE, 97, 112-118.

Ø   Yeh, Y. R., Tzeng, Y. J. Tsai, S. W. 2018. “Quantitative improvements and insights into CALB-catalyzed resolution of trans- and cis-2-phenylcyclopropyl azolides”, ChemistrySelect 3, 5353-5360.

Ø     Wu, T. Y., Lai, Y. R., Tsai, S. W. 2018. “CALB-catalyzed two-step alcoholytic desymmetrization of 3-methylglutaric diazolides in MTBE”, Appl. Biochem. Biotechnol. 185, 578-592.

Ø    Lee, M. T., Lee, I. C., Tsai, S. W., Chen, C. H., Wu, M. H., Juang, Y. J. 2017. “Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch”, JTIChE, 70, 42-48. 

Ø    Lee, I. C., Lin, W. M., Shu, J. C., Tsai, S. W., Chen, C. H., Tsai, M. T. 2017. “Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice”, J. Biomed. Mater. Research, Part A, 7, 5067-5075.

Ø    Lee, I. C., Wu, Y. C., Tsai, S. W., Chen, C. H., Wu, M. H. 2017. “Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for: In vivo insulin transdermal delivery“, RSC Advances, 7, 5067-5075.

Ø     Tsai, S. W. 2017. “Quantitative insights into one-pot sequential asymmetric enzymatic catalytic processes”, JTIChE, 74, 79-88.

Ø     Hsu, C. H., Tsai, S. W. 2017. “Lipase-catalysed two-step desymmetrization of 2-methylmalonic dipyrazolide for preparation of optically pure enantiomer in organic solvents“ , Biocat. Biotrans. 35, 460-467.

Ø  Kao, J. Y., Tsai, S. W. 2016 “Kinetic analysis for lipase-catalyzed regioselective methanolysis of (R)- and (S)-2-methylglutaric dipyrazolides for preparation of (R)-methyl 2-methyl-5-oxo-

5-[1H-pyrazol-1-yl)pentanoate and (S)-methyl 4-methyl-5-oxo-5-[1H- pyrazol-1-yl)pentanoate”, JTIChE, 59, 120-125.

Ø  Tsai, S. W., 2016. “Enantiopreference of Candida antarctica lipase B toward carboxylic acids: substrate models and enantioselectivity thereof”, J. Mol. Cat. B: Enzymatic, 127, 98-116.

Ø  Hsiao, H. T. Lin, S. Y. Tsai, S. W. 2016. “Quantitative insights and

Improvements of enzyme activity and stereoselectivity for CALB-catalyzed alcoholysis in two-step desymmetrization,” J. Mol. Cat. B: Enzymatic, 127, 82-88.

Ø  Chan, P. H., Tsai, S. W. 2016. “Two-step desymmetrization of dipyrazolidyl 3-phenylglutarate via lipase-catalyzed hydrolysis in organic solvents,” Chem. Eng. Sci., 139, 41-48.

Ø   Ko, P. T. Lee, I. C. Chen, M. C. Tsai, S. W. 2015. “Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds”, JTIChE, 51, 1-8.

Ø  Huang, Y. K. Tsai, S. W., 2014. “Kinetic and thermodynamic analysis of Candida antarctica lipase B-catalyzed alcoholytic resolution of (R,S)-β-butyrolactone in organic solvents”, App. Microb. Biotechnol., 98, 621-628.

Ø  Wu, C. H., Wang, P. Y., Tsai, S. W., 2013. “Kinetic analysis for lipase-catalyzed hydrolysis of (R,S)-1,2,4-triazolides derived from N-Cbz-proline and (R,S)-N-Cbz-pipecolic acid”, JTIChE, 44, 146-151.

Ø   Wu, C. H., Pen, C. W., Wang, P. Y., Tsai, S. W., 2013. “An efficient lipase-catalyzed enantioselective hydrolysis of (R,S)-azolides derived from N-protected proline, pipecolic acid, and nipecotic acid”, App. Microb. Biotechnol. 97, 1581-1587.

Ø  Cheng, Y. L.,   Wu, C. H., Wang, P. Y., Tsai, S. W. 2012. “Kinetic and thermodynamic analysis for lipase-catalyzed hydrolytic resolution of (R,S)-alcohols though their azolyl carbamates”, Biopro. Biosys. Eng.35, 953-962.

Ø   Chen, J. R., Wu, C. H., Wang, P. Y., Tsai, S. W. 2012. “Kinetic and thermodynamic investigation of lipase-catalyzed hydrolysis of (R,S)-3-phenylbutyl azolides” , IEC Research 51, 3580-3586.

Ø  Kao, M. F., Lu, P. Y., Kao, J. Y., Wang, P. Y., Wu, A. C., Tsai, S. W., 2012. “(R,S)-2-Chlorophenoxyl pyrazolides as extreme substrates for improving lipase-catalyzed hydrolytic resolution”, Chirality 24, 60-66.

Ø   Wu, A. C., Wang, P. Y., Tsai, S. W., 2012. “Lipase-catalyzed regioselective hydrolysis of 3(5)-methylpyrazole-N-carboxylates in water-saturated organic solvents”, J. Mol. Cat. B: Enzymatic, 74, 41-47.

Ø  Cho, S. H., Wang, P. Y., Tsai, S. W., 2011. “Lipase-catalyzed hydrolytic resolution of (R,S)-3-hydroxy-3-phenylpropionates in biphasic media”, JTIChE 42, 408-412.

Ø   Ciou, J. F., Wang, P. Y., Wu, A. C., Tsai, S. W., 2011. “Lipase-catalyzed alcoholytic resolution of (R,S)-flurbiprofenyl azolides for preparation of (R)-NO-flurbiprofen ester prodrugs,” Proc. Biochem. 46, 960-965.

Ø  Lin, Y. S., Wang, P. Y., Wu, A. C., Tsai, S. W., 2011. “Lipase-catalyzed enantioselective resolution of (R,S)-N-2-methylalkanoyl-3-

(2-pyridyl)pyrazoles in organic solvents”, J. Mol. Cat. B: Enzymatic, 68, 245-249.


Ø  Tsai, S. W. and Wang P. Y. Method for producing an optically active compound”, US Patent 8377660 (2013); ROC Patent 1388667 (2013).

Ø  Tsai, S. W. “Enzymatic resolution of an alpha-substituted carboxylic acid or an ester thereof by Carica papaya lipase”, Japan Patent 4247545 (2009); ROC Patent 276687 (2007).

Ø  Tsai, S. W. and Chang C. S. “Processes for preparing optically active (S)-a-aryl propionic acid or ester thereof,” US Patent 6201151 (2001); ROC Patent 150558 (2002).