Your browser does not support JavaScript!
長庚大學 化工與材料工程學系
Department of Chemical and Materials Engineering, Chang Gung University
陳志平 教授

陳志平 教授

Tel:03-2118800 ext. 5298

生物工程實驗室 ext. 5604

Fax: 03-2118668



























美國United Biomedical Inc.



















天然與合成高分子生醫材料的開發。包括天然高分子生醫材料(膠原蛋白、幾丁質、幾丁聚醣、透明質酸、蠶絲蛋白)的生產、分離純化、加工、與利用具活性的生 物分子之修飾。合成高分子生醫材料的化學合成製備、性質分析、與利用電漿反應器進行改質。利用所得的各式生醫材料為骨架,配合各式生物反應器,進行適用於 體內或體外的肝組織工程、軟骨組織工程、及人工皮膚等研究。

以有機或無機材料進行生物分子、酵素、與細胞的固定化,利用生物催化方式應用於特化品的生產、廢水處理、生化分離、及生醫用途。目前研究工作主要針對各型 酯頹及光學活性藥物的生產、生質柴油與生質酒精的生產、藥物制放、人工器官開發、染整廢水脫色、及廢水重金屬去除等。



1.           C.H. Chen, M.Y. Lee, V.B.H. Shyu, Y.C. Chen, C.T. Chen, J.P. Chen*. 2014. Surface modification of polycaprolactone scaffolds fabricated via selective laser sintering for cartilage tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 40, 389-397.

2.           G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen*. 2014. Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohrdrate Polymers, 111, 288–297. Y.J. Lu, C.W. Lin, H.W. Yang, K.J. Lin, S.P. Wey, C.L. Sun, K.C. Wei, T.C. Yen, C.I. Lin, C.C.M. Ma, J.P. Chen*. 2014. Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy. Carbon, 74, 83-95.

3.           C.H. Chen, J.M.J. Liu, C.K. Chua, S.M. Chou, V.B.H. Shyu, J.P. Chen*. 2014. Cartilage tissue engineering with silk fibroin scaffolds fabricated by indirect additive manufacturing technology. Materials, 7, 2104-2119.

4.           H.Y. Hou, S.H. Fu, C.H. Liu, J.P. Chen, B.R.S. Hsu. 2014. The graft survival protection of subcutaneous allogeneic islets with hydrogel grafting and encapsulated by CTLA4Ig and IL1ra. Polymer Journal, 46, 136-144.

5.           C.H. Chen, V.B.H. Shyu, J.P. Chen, M.Y. Lee. 2014. Selective laser sintered poly-ε-caprolactone scaffold hybridized with collagen hydrogel for cartilage tissue engineering. Biofabrication, 6, 015004.

6.           M.Y. Lee, W.W. Tsai, H.J. Chen, J.P. Chen, C.H. Chen, W.L. Yeh, J. An. 2013. Laser sintered porous polycaprolacone scaffolds loaded with hyaluronic acid and gelatin-grafted thermoresponsive hydrogel for cartilage tissue engineering. Bio-Medical Materials and Engineering, 23, 533-543.

7.           H.T.Liao, J.P. Chen*, M.Y. Lee. 2013. Bone tissue engineering with adipose-derived stem cells in bioactive composites of laser-sintered porous polycaprolactone scaffolds and platelet-rich plasma. Materials, 6, 4911-4929.

8.           K.H. Chang, H.T. Liao, J.P. Chen*. 2013. Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies. Acta Biomaterialia, 9, 9012–9026.

9.           J.P. Chen*, M.J. Tsai, H.T. Liao. 2013. Incorporation of biphasic calcium phosphate microparticles in injectable thermoresponsive hydrogel modulates bone cell proliferation and differentiation. Colloids and Surfaces B: Biointerfaces, 110, 120–129.

10.        J.P. Chen* and F.N. Chang. 2012. Preparation and characterization of hydroxyapatite/gelatin composite membranes for immunoisolation. Applied Surface Science, 262, 176-183.

11.        J.P. Chen*, C.Y. Kuo, and W.L. Lee. 2012. Thermo-responsive wound dressings by grafting chitosan and poly(N-isopropylacrylamide) to plasma-induced graft polymerization modified non-woven fabrics. Applied Surface Science, 262, 95-101.

12.        J.P. Chen*, P.C. Yang, Y.H. Ma, S.J. Tu, and Y.J. Lu. 2012. Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle. International Journal of Nanomedicine, 7, 5137-5149.

13.        J. An, C.K. Chua, K.F. Leong, C.H. Chen, and J.P. Chen. 2012. Solvent-free fabrication of three dimensionally aligned polycaprolactone microfibers for engineering of anisotropic tissues. Biomedical Microdevices, 14, 863-872.

14.        Y.J. Lu, H.W. Yang, S.C. Hung, C.Y. Huang, S.M. Li, C.C.M. Ma, P.Y. Chen, H.C. Tsai, K.C. Wei, and J.P. Chen.* 2012. Improving thermal stability and treatment efficacy of BCNU to glioma cells using PAA-functionalized graphene oxide. International Journal of Nanomedicine, 7, 1737-1747.

15.        J.P. Chen, S.H. Chen, and G..J. Lai. 2012. Preparation and characterization of biomimetic silk fibroin/chitosan composite nanofibers by electrospinning for osteoblasts culture. Nanoscale Research Letters, 7:170, doi:10.1186/1556-276X-7-170.

16.        Y.J. Lu, K.C. Wei, C.C. Ma, S.Y. Yang, J.P. Chen.* 2012. Dual Targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes. Colloids and Surfaces B-Biointerfaces, 89, 1-9.

17.        J.P. Chen*, H.T. Liao, and T.H. Chen. 2011. Cultivation of chondrocytes and meniscus cells in thermo-responsive hydrogels containing chitosan and hyaluronic acid under mechanical tensile stimulation. Journal of Mechanics in Medicine and Biology, 11, 1003-1015.

18.        C.H. Chen, J.P. Chen and M.Y. Lee. 2011. Effects of gelatin modification on rapid prototyping PCL scaffolds for cartilage engineering, Journal of Mechanics in Medicine and Biology, 11, 993-1002.

19.        M.Y. Lee, S.W. Liu, J.P. Chen, H.T. Liao, W.W. Tsai, H.C. Wang. 2011. In vitro experiments on laser sintered porous PCL scaffolds with polymer hydrogel for bone repair. Journal of Mechanics in Medicine and Biology, 11, 983-992.

20.        J.P. Chen*, P.C. Yang, and Y.H. Ma, and Y.J. Lu. 2011. Superparamagnetic iron oxide nanoparticles for delivery of tissue plasminogen activator. Journal of Nanoscience and Nanotechnology, 11, 11089-11094.

21.        H.T. Liao, C.T. Chen, J.P. Chen.* 2011. Osteogenic differentiation and ectopic bone formation of canine bone marrow-derived mesenchymal stem cells in injectable thermo-responsive polymer hydrogel. Tissue Engineering, Part C, 17, 1139-1149.

22.        H.T. Liao, K.H. Chang, J.P. Chen. 2011. Osteogenesis of adipose-derived stem cells on three-dimensional, macroporous gelatin–hyaluronic acid cryogels. Biomedical Engineering: Applications, Basis and Communications, 23, 127-133.

23.        J.P. Chen* and Y.S. Chang. 2011. Preparation and characterization of composite nanofibers of polycaprolactone and nanohydroxyapatite for osteogenic differentiation of mesenchymal stem cells. Colloids and Surfaces B: Biointerfaces, 86, 169-175.

24.        H.T. Liao, C.T. Chen, C.H. Chen, J.P. Chen, and J.C. Tsai. 2011. Combination of guided osteogenesis with autologous platelet-rich fibrin glue and mesenchymal stem cell for reconstruction of mandibular defects in canine model. Journal of Trauma, 70, 228-237.

25.        J.P. Chen, Y.L. Leu, C.L.Fang, C.H. Chen, and J.Y. Fang. 2011. Thermosensitive hydrogels composed of hyaluronic acid and gelatin as carriers for the intravesical administration of cisplatin. Journal of Pharmaceutical Sciences, 100, 655-666.

26.        J.P. Chen*, P.C. Yang, Y.H. Ma and T. Wu. 2011. Characterization of chitosan magnetic nanoparticles for in situ delivery of tissue plasminogen activator. Carbohydrate Polymers, 84, 364-372.

27.        J.P. Chen* and C.H. Su. 2011. Surface modification of electrospun PLLA nanofibers by plasma treatment and cationized gelatin immobilization for cartilage tissue engineering. Acta Biomaterialia, 7, 234-243.

28.        P.Y. Chen, H.L. Liu, M.Y. Hua, H.W. Yang, C.Y. Huang, P.C. Chu, L.A. Lyu, I.C. Tseng, L.Y. Feng, H.C. Tsai, S.M. Chen, Y.J. Lu, J.J. Wang, T.C. Yen, Y.H. Ma, T. Wu, J.P. Chen, J.I. Chuang, J.W. Shin, C. Hsueh, and K.C. Wei. 2010. Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment. Neuro-Oncology, 12, 1050-1060.

29.        J.P. Chen* and Y. Chiang. 2010. Bioactive electrospun silver nanoparticles- containing polyurethane nanofibers as wound dressings. Journal of Nanoscience and Nanotechnology, 10, 7560-7564.

30.        J.P. Chen*, S.F. Li and Y.P. Chiang. 2010. Bioactive collagen-grafted poly-L-lactic acid nanofibrous membrane for cartilage tissue engineering. Journal of Nanoscience and Nanotechnology, 10, 5393-5398.

31.        J.P. Chen* and J.H. Lin. 2010. Optimization of Biodiesel Production Catalyzed by Fungus Cells Immobilized in Fibrous Supports. Applied Biochemistry and Biotechnology, 161, 181-194.

32.        Y.T. Chen, S.H. Fu, J.P. Chen, and B.R.S. Hsu. 2009. AMT, an inducible nitric oxide synthase inhibitor, enhances islet engraftment. Transplantation Proceedings, 41, 1786–1788.

33.        J.P. Chen*, K.S Ho, Y.P. Chiang, K.W. Wu. 2009. Fabrication of electrospun poly(methyl methacrylate) nanofibrous membranes by statistical approach for application in enzyme immobilization by statistical approach for application in enzyme immobilization. Journal of Membrane Science, 340, 9-15.

34.        Y.H. Ma, S.Y. Wu, T. Wu, Y.J. Chang, M.Y. Hua, J.P. Chen*. 2009. Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles. Biomaterials, 30, 3343-3351.

35.        B.R. Huang, P.Y. Chen, C.Y. Huang, S.M. Jung, Y.H. Ma, T. Wu, J.P. Chen*, K.C. Wei. 2009. The bioavailability of magnetic nanoparticles to the brain. Journal of Magnetism and Magnetic Materials, 321, 1604-1609.

36.        L.B. Jeng, H.Y. Chung, T.M. Lin, J.P. Chen, Y.L. Chen, Y.L. Lu, Y.J. Wang, and S.C.N. Chang. 2009. Characterization and osteogenic effects of mesenchymal stem cells on microbeads composed of hydroxyapatite nanoparticles/reconstituted collagen. Journal of Biomedical Materials Research Part A, 91, 886-893.

37.        J.P. Chen* and T.H. Cheng. 2009. Preparation and evaluation of thermo-reversible copolymer hydrogels containing chitosan and hyaluronic acid as injectable cell carriers. Polymer, 50, 107-116.