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長庚大學 化工與材料工程學系
Department of Chemical and Materials Engineering, Chang Gung University
陳志平 教授

陳志平 教授

Tel:03-2118800 ext. 5298

生物工程實驗室 ext. 5604

Fax: 03-2118668



























美國United Biomedical Inc.



















天然與合成高分子生醫材料的開發。包括天然高分子生醫材料(膠原蛋白、幾丁質、幾丁聚醣、透明質酸、蠶絲蛋白)的生產、分離純化、加工、與利用具活性的生 物分子之修飾。合成高分子生醫材料的化學合成製備、性質分析、與利用電漿反應器進行改質。利用所得的各式生醫材料為骨架,配合各式生物反應器,進行適用於 體內或體外的肝組織工程、軟骨組織工程、及人工皮膚等研究。

以有機或無機材料進行生物分子、酵素、與細胞的固定化,利用生物催化方式應用於特化品的生產、廢水處理、生化分離、及生醫用途。目前研究工作主要針對各型 酯頹及光學活性藥物的生產、生質柴油與生質酒精的生產、藥物制放、人工器官開發、染整廢水脫色、及廢水重金屬去除等。



1.       T.E. Lin, Y.J. Lu, C.L. Sun, H. Pick, J.P. Chen, A. Lesch, H.H. Girault. 2017. From tissues to organs: soft electrochemical probes for mapping the distribution of biomarkers and injected nanomaterials in animal and human tissues. Angewandte Chemie International Edition, DOI: 10.1002/ange.201709271.

2.       Y.T. Fong, C.H. Chen, J.P. Chen.* 2017. Intratumoral delivery of doxorubicin on folate-conjugated graphene oxide by in-situ forming thermo-sensitive hydrogel for breast cancer therapy. Nanomaterials, 7, 388.

3.       P.Y. Chou, S.H. Chen, C.H. Chen, S.H. Chen, Y.T Fong, J.P. Chen.* 2017. Thermo-responsive in-situ forming hydrogels as barriers to prevent post-operative peritendinous adhesion. Acta Biomaterialia, 63, 85-95.

4.       C.S. Chang,, C.G. Wallace, Y.C. Hsiao, Y.J. Hsieh, Y.C. Wang, N.H. Chen, Y.F. Liao, E.J.W. Liou, P.K.T. Chen, J.P. Chen, Y.R. Chen. 2017. Airway changes after cleft orthognathic surgery evaluated by three-dimensional computed tomography and overnight polysomnographic study. Scientific Reports, 7, 12260

5.       C.H Chen, S.H. Chen, C.Y. Kuo, M.L. Li, J.P. Chen.* 2017. Response of dermal fibroblasts to biochemical and physical cues in aligned polycaprolactone/silk fibroin nanofiber scaffolds for application in tendon tissue engineering. Nanomaterials, 7, 219.

6.       C.H. Chen, S.H. Chen, S.H. Mao, M.J. Tsai, P.Y. Chou, C.H. Liao, J.P. Chen.* 2017. Injectable thermosensitive hydrogel containing hyaluronic acid and chitosan as a barrier for prevention of postoperative peritoneal adhesion. Carbohydrate Polymers, 173, 721-731.

7.       C.L. Yang, J.P. Chen, K.C. Wei, J.Y. Chen, C.W. Huang, Z.X. Liao. 2017. Release of doxorubicin by a folate-grafted, chitosan-coated magnetic nanoparticle. Nanomaterials, 7, 85. (Equal contribution)

8.       S. Lin, Y.C. Hsiao, Y. C., J.J. Huang, C.S. Chang, P.K. Chen, J.P. Chen, L.J. Lo, Y.R. Chen. 2017. Minimal invasive rhinoplasty: fat injection for nasal dorsum contouring. Annals of Plastic Surgery, 78(3 Suppl 2), S117-S123.

9.       H.L. Hsu, J.P. Chen.* 2017. Preparation of thermosensitive magnetic liposome encapsulated recombinant tissue plasminogen activator for targeted thrombolysis. Journal of Magnetism and Magnetic Materials, 427, 188–194.

10.    Y.C. Lu, F.Y. Chang, S.J. Tu, J.P. Chen, Y.H. Ma. 2017. Cellular uptake of magnetite nanoparticles enhanced by NdFeB magnets in staggered arrangement. Journal of Magnetism and Magnetic Materials, 427, 71–80.

11.    Y.S. Huang, Y.J. Lu, J.P. Chen.* 2017. Magnetic graphene oxide as a carrier for targeted delivery of chemotherapy drugs in cancer therapy. Journal of Magnetism and Magnetic Materials, 427, 34–40.

12.    K.T. Shalumon, C. Sheu, Y.T. Fong, H.T. Liao, J.P. Chen.* 2016. Microsphere-based hierarchically juxtapositioned biphasic scaffolds prepared from poly(lactic-co-glycolic acid) and nanohydroxyapatite for osteochondral tissue engineering. Polymers, 8, 429.

13.    C.H. Chen, C.Y. Kuo, Y.J. Wang, J.P. Chen.* 2016. Dual function of glucosamine in gelatin/hyaluronic acid cryogel to modulate scaffold mechanical properties and to maintain chondrogenic phenotype for cartilage tissue engineering. International Journal of Molecular Sciences, 17, 1957.

14.    C. Sheu, K.T. Shalumon, C.H. Chen, C.Y. Kuo, Y.T. Fong, J.P. Chen.* 2016. Dual crosslinked hyaluronic acid nanofibrous membranes for prolonged prevention of post-surgical peritoneal adhesion. Journal of Materials Chemistry B, 4, 6680-6693.

15.    C.S. Chang, C.G. Wallace, Y.C. Hsiao, Y.T. Chiu, B.C.J. Pai, I.J. Chen, Y.F. Liao, E.J.W. Liou, P.K.T. Chen, J.P. Chen, M.S. Noordhoff. 2016. Difference in the surgical outcome of unilateral cleft lip and palate patients with and without pre-alveolar bone graft orthodontic treatment. Scientific Reports, 6, 23597.

16.    C.S. Chang, Y.C. Hsiao, J.J. Huang, J.P. Chen, P.K.T. Chen, G.C.W. Kang. 2016. Aesthetic patient-centric approach to a unilateral zygomaticomaxillary fracture: computer-guided osteotomy of the non-injured side. Aesthetic Surgery Journal, 36(5), NP184-NP186.

17.    J.P. Chen,* C.H. Liu, H.L. Hsu, T. Wu, Y.J. Lu, Y.H. Ma. 2016. Magnetically controlled release of recombinant tissue plasminogen activator from chitosan nanocomposites for targeted thrombolysis. Journal of Materials Chemistry B, 4, 2578-2590.

18.    H.T. Liao, K.T. Shalumon, K.H. Chang, C. Sheu, J.P. Chen.* 2016. Investigation of synergistic effects of inductive and conductive factors in gelatin-based cryogels for bone tissue engineering. Journal of Materials Chemistry B, 4, 1827-1841.

19.    K.T. Shalumon, G.J Lai, C.H. Chen, J.P. Chen.* 2015. Modulation of bone-specific tissue regeneration by incorporating bone morphogenetic protein and controlling the shell thickness of silk fibroin/chitosan/nanohydroxyapatite core–shell nanofibrous membranes. ACS Applied Materials & Interface, 7, 21170-21181.

20.    C.H. Chen, S.H. Chen, K.T. Shalumon, J.P. Chen.* 2015. Dual functional core–sheath electrospun hyaluronic acid/polycaprolactone nanofibrous membranes embedded with silver nanoparticles for prevention of peritendinous adhesion. Acta Biomaterialia, 26, 225-235.

21.    C.H. Chen, S.H. Chen, K.T. Shalumon, J.P. Chen.* 2015. Prevention of peritendinous adhesions with electrospun polyethyleneglycol/polycaprolactone nanofibrous membranes. Colloids and Surfaces B: Biointerfaces, 133, 221-230.

22.    K.T. Shalumon, J.P. Chen.* 2015. Scaffold-based drug delivery for cartilage tissue regeneration. Current Pharmaceutical Design, 21, 1979-1990.

23.    G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen.* 2015. Response of human mesenchymal stem cells to intra-fibrillar nanohydroxyapatite content and extra-fibrillar nanohydroxyapatite in biomimetic chitosan/silk fibroin/nanohydroxyapatite nanofibrous membrane scaffolds. International Journal of Nanomedicine, 10, 567–584.

24.    C.Y. Kuo, C.H. Chen, C.Y. Hsiao, J.P. Chen.* 2015. Incorporation of chitosan in biomimetic gelatin/chondroitin-6-sulfate/hyaluronan cryogel for cartilage tissue engineering. Carbohydrate Polymers, 117, 722–730.

25.    S.H. Chen, C.H. Chen, Y.T. Fong, J.P. Chen.* 2014. Prevention of peritendinous adhesions with electrospun chitosan-grafted polycaprolactone nanofibrous membranes. Acta Biomaterialia, 10, 4971-4982.

26.    S.H. Chen, C.H. Chen, K.T. Shalumon, J.P. Chen.* 2014. Preparation and characterization of anti-adhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion. International Journal of Nanomedicine, 9, 4079-4092.

27.    G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen.* 2014. Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohydrate Polymers, 111, 288-297.

28.    C.H. Chen, M.Y. Lee, V.B.H. Shyu, Y.C. Chen, C.T. Chen, J.P. Chen.* 2014. Surface modification of polycaprolactone scaffolds fabricated via selective laser sintering for cartilage tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 40, 389-397. 

29.    Y.J. Lu, C.W. Lin, H.W. Yang, K.J. Lin, S.P. Wey, C.L. Sun, K.C. Wei, T.C. Yen, C.I. Lin, C.C.M. Ma, J.P. Chen.* 2014. Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy. Carbon, 74, 83-95.

30.    C.H. Chen, J.M.J. Liu, C.K. Chua, S.M. Chou, V.B.H. Shyu, J.P. Chen.* 2014. Cartilage tissue engineering with silk fibroin scaffolds fabricated by indirect additive manufacturing technology. Materials, 7, 2104-2119.

31.    H.Y. Hou, S.H. Fu, C.H. Liu, J.P. Chen, B.R.S. Hsu. 2014. The graft survival protection of subcutaneous allogeneic islets with hydrogel grafting and encapsulated by CTLA4Ig and IL1ra. Polymer Journal, 46, 136-144.

32.    C.H. Chen, V.B.H. Shyu, J.P. Chen, M.Y. Lee. 2014. Selective laser sintered poly-ε-caprolactone scaffold hybridized with collagen hydrogel for cartilage tissue engineering. Biofabrication, 6, 015004.

33.    M.Y. Lee, W.W. Tsai, H.J. Chen, J.P. Chen, C.H. Chen, W.L. Yeh, J. An. 2013. Laser sintered porous polycaprolacone scaffolds loaded with hyaluronic acid and gelatin-grafted thermoresponsive hydrogel for cartilage tissue engineering. Bio-Medical Materials and Engineering, 23, 533-543.

34.    H.T. Liao, J.P. Chen*, M.Y. Lee. 2013. Bone tissue engineering with adipose-derived stem cells in bioactive composites of laser-sintered porous polycaprolactone scaffolds and platelet-rich plasma. Materials, 6, 4911-4929.

35.    K.H. Chang, H.T. Liao, J.P. Chen.* 2013. Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies. Acta Biomaterialia, 9, 9012–9026. 

36.    J.P. Chen,* M.J. Tsai, H.T. Liao. 2013. Incorporation of biphasic calcium phosphate microparticles in injectable thermoresponsive hydrogel modulates bone cell proliferation and differentiation. Colloids and Surfaces B: Biointerfaces, 110, 120-129.

37.    J.P. Chen* and F.N. Chang. 2012. Preparation and characterization of hydroxyapatite/gelatin composite membranes for immunoisolation. Applied Surface Science, 262, 176-183.

38.    J.P. Chen,* C.Y. Kuo, and W.L. Lee. 2012. Thermo-responsive wound dressings by grafting chitosan and poly(N-isopropylacrylamide) to plasma-induced graft polymerization modified non-woven fabrics. Applied Surface Science, 262, 95-101.

39.    J.P. Chen,* P.C. Yang, Y.H. Ma, S.J. Tu, and Y.J. Lu. 2012. Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle. International Journal of Nanomedicine, 7, 5137-5149.

40.    J. An, C.K. Chua, K.F. Leong, C.H. Chen, and J.P. Chen. 2012. Solvent-free fabrication of three dimensionally aligned polycaprolactone microfibers for engineering of anisotropic tissues. Biomedical Microdevices, 14, 863-872.

41.    Y.J. Lu, H.W. Yang, S.C. Hung, C.Y. Huang, S.M. Li, C.C.M. Ma, P.Y. Chen, H.C. Tsai, K.C. Wei, and J.P. Chen.* 2012. Improving thermal stability and treatment efficacy of BCNU to glioma cells using PAA-functionalized graphene oxide. International Journal of Nanomedicine, 7, 1737-1747.

42.    J.P. Chen,* S.H. Chen, and G..J. Lai. 2012. Preparation and characterization of biomimetic silk fibroin/chitosan composite nanofibers by electrospinning for osteoblasts culture. Nanoscale Research Letters, 7, 170. 

43.    Y.J. Lu, K.C. Wei, C.C. Ma, S.Y. Yang, J.P. Chen.* 2012. Dual Targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes. Colloids and Surfaces B-Biointerfaces, 89, 1-9.